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    basR DNA-binding transcriptional dual regulator BasR [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948631, updated on 3-Dec-2024

    Summary

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    Official Symbol
    basR
    Official Full Name
    DNA-binding transcriptional dual regulator BasR
    Primary source
    ECOCYC:EG11615
    Locus tag
    b4113
    See related
    ASAP:ABE-0013466
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4106; pmrA
    Summary
    BasS is the cognate sensor protein of the BasSR two-component system. [More information is available at EcoGene: EG11615]. The transcriptional regulatory protein BasR is part of the two-component BasS/BasR signal transduction system . [More information is available at EcoCyc: EG11615].
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    Genomic context

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    Sequence:
    NC_000913.3 (4333282..4333950, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene osmolyte:H(+) symporter ProP Neighboring gene small regulatory membrane protein PmrR Neighboring gene sensor histidine kinase BasS Neighboring gene phosphoethanolamine transferase EptA Neighboring gene arginine:agmatine antiporter Neighboring gene DNA-binding transcriptional activator AdiY

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Spontaneous pmrA mutants of Salmonella typhimurium LT2 define a new two-component regulatory system with a possible role in virulence. Roland KL, et al. J Bacteriol, 1993 Jul. PMID 8391535, Free PMC Article
    2. Strong cross-system interactions drive the activation of the QseB response regulator in the absence of its cognate sensor. Guckes KR, et al. Proc Natl Acad Sci U S A, 2013 Oct 8. PMID 24062463, Free PMC Article
    3. Nonclonal Emergence of Colistin Resistance Associated with Mutations in the BasRS Two-Component System in Escherichia coli Bloodstream Isolates. Janssen AB, et al. mSphere, 2020 Mar 11. PMID 32161146, Free PMC Article
    4. Contribution of Novel Amino Acid Alterations in PmrA or PmrB to Colistin Resistance in mcr-Negative Escherichia coli Clinical Isolates, Including Major Multidrug-Resistant Lineages O25b:H4-ST131-H30Rx and Non-x. Sato T, et al. Antimicrob Agents Chemother, 2018 Sep. PMID 29914952, Free PMC Article
    5. The contribution of PmrAB to the virulence of a clinical isolate of Escherichia coli. Warner DM, et al. Virulence, 2013 Oct 1. PMID 23921442, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A novel type of colistin resistance genes selected from random sequence space.
      Title: A novel type of colistin resistance genes selected from random sequence space.
    2. Nonclonal Emergence of Colistin Resistance Associated with Mutations in the BasRS Two-Component System in Escherichia coli Bloodstream Isolates.
      Title: Nonclonal Emergence of Colistin Resistance Associated with Mutations in the BasRS Two-Component System in Escherichia coli Bloodstream Isolates.
    3. this study revealed that the colistin resistance mechanism of E. coli clinical isolates is due to novel amino acid substitutions and deletions in PmrAB that confer phosphoethanolamine transferase modification of lipid A.
      Title: Contribution of Novel Amino Acid Alterations in PmrA or PmrB to Colistin Resistance in mcr-Negative Escherichia coli Clinical Isolates, Including Major Multidrug-Resistant Lineages O25b:H4-ST131-H30Rx and Non-x.
    4. All components of the QseBC and PmrAB two-component systems (TCSs) are required for proper response to ferric iron.
      Title: Signaling by two-component system noncognate partners promotes intrinsic tolerance to polymyxin B in uropathogenic Escherichia coli.
    5. These findings suggest a role for the PmrAB two-component regulatory system in the virulence of Escherichia coli in a murine pyelonephritis model.
      Title: The contribution of PmrAB to the virulence of a clinical isolate of Escherichia coli.
    6. The PmrA response regulator contributes to qseB transcription in the absence of QseC and PmrA specifically binds the qseBC promoter, indicative of a direct regulation of qseBC gene transcription by PmrAB under physiological conditions.
      Title: Strong cross-system interactions drive the activation of the QseB response regulator in the absence of its cognate sensor.
    7. More than 20 novel targets are regulated by BasS-BasR two-component system.
      Title: Novel regulation targets of the metal-response BasS-BasR two-component system of Escherichia coli.
    8. PmrA-dependent inhibition of LpxT is required for phosphoethanolamine decoration of lipid A, which is shown here to be critical for Escherichia coli to resist the bactericidal activity of polymyxin.
      Title: Activation of PmrA inhibits LpxT-dependent phosphorylation of lipid A promoting resistance to antimicrobial peptides.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphorelay response regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphorelay response regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within phosphorelay signal transduction system IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phosphorelay signal transduction system IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to antibiotic IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to iron(III) ion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to iron(III) ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein-DNA complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DNA-binding transcriptional dual regulator BasR

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4333282..4333950 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418537.1 DNA-binding transcriptional dual regulator BasR [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418537.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5B9AM05
      Conserved Domains (1) summary
      PRK10643
      Location:1 → 222
      PRK10643; two-component system response regulator PmrA
    Nucleotide Protein
    Heading Accession and Version

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