fumB fumarase B [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

Official Symbol: fumB
Official Full Name: fumarase B
Primary source: ECOCYC:EG10357
Locus tag: b4122
See related: ASAP:ABE-0013501
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK4115
Summary: FumB is required for anaerobic D-tartrate utilization and fumB mutants have reduced D-tartrate dehydratase activity (Kim, 2007). [More information is available at EcoGene: EG10357]. One of three isozymes in Escherichia coli, fumarase B is a Class I fumarase. [More information is available at EcoCyc: EG10357].
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NC_000913.3 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables 4 iron, 4 sulfur cluster binding	IDA Inferred from Direct Assay more info	PubMed
enables 4 iron, 4 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables D(-)-tartrate dehydratase activity	IDA Inferred from Direct Assay more info	PubMed
enables D(-)-tartrate dehydratase activity	IEA Inferred from Electronic Annotation more info
enables D(-)-tartrate dehydratase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables fumarate hydratase activity	IBA Inferred from Biological aspect of Ancestor more info
enables fumarate hydratase activity	IDA Inferred from Direct Assay more info	PubMed
enables fumarate hydratase activity	IEA Inferred from Electronic Annotation more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	IEP Inferred from Expression Pattern more info	PubMed
involved_in generation of precursor metabolites and energy	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within single-species biofilm formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tricarboxylic acid cycle	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within tricarboxylic acid cycle	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	HDA more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

NP_418546.1

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The following sections contain reference sequences that belong to a specific genome build. Explain