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    dtpC dipeptide/tripeptide:H(+) symporter DtpC [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948644, updated on 3-Dec-2024

    Summary

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    Official Symbol
    dtpC
    Official Full Name
    dipeptide/tripeptide:H(+) symporter DtpC
    Primary source
    ECOCYC:EG12469
    Locus tag
    b4130
    See related
    ASAP:ABE-0013524
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4124; yjdL
    Summary
    Major Facilitator Superfamily (MFS). [More information is available at EcoGene: EG12469]. The YjdL protein is an uncharacterised member of the POT family of peptide transporters . [More information is available at EcoCyc: EG12469].
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    Genomic context

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    Sequence:
    NC_000913.3 (4354954..4356411, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene toxin of the GhoTS toxin-antitoxin system Neighboring gene lysine--tRNA ligase/Ap4A synthetase/Ap3A synthetase Neighboring gene lysine decarboxylase 1 Neighboring gene lysine:cadaverine antiporter

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Critical role of a conserved transmembrane lysine in substrate recognition by the proton-coupled oligopeptide transporter YjdL. Jensen JM, et al. Int J Biochem Cell Biol, 2014 Oct. PMID 25261786
    2. DtpB (YhiP) and DtpA (TppB, YdgR) are prototypical proton-dependent peptide transporters of Escherichia coli. Harder D, et al. FEBS J, 2008 Jul. PMID 18485005
    3. New insights into the substrate specificities of proton-coupled oligopeptide transporters from E. coli by a pH sensitive assay. Prabhala BK, et al. FEBS Lett, 2014 Feb 14. PMID 24440353
    4. Ligand binding analyses of the putative peptide transporter YjdL from E. coli display a significant selectivity towards dipeptides. Ernst HA, et al. Biochem Biophys Res Commun, 2009 Nov 6. PMID 19703419
    5. Projection structure of DtpD (YbgH), a prokaryotic member of the peptide transporter family. Casagrande F, et al. J Mol Biol, 2009 Dec 11. PMID 19782088

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate that Lys117 interacts with the dipeptide carboxylate in proton-coupled oligopeptide transporter YjdL.
      Title: Critical role of a conserved transmembrane lysine in substrate recognition by the proton-coupled oligopeptide transporter YjdL.
    2. These results clearly indicate that unlike most proton-dependent oligopeptide transporters characterized to date, including YdgR and YhiP, YjdL shows significantly higher specificity towards dipeptides.
      Title: Ligand binding analyses of the putative peptide transporter YjdL from E. coli display a significant selectivity towards dipeptides.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables dipeptide transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dipeptide transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables peptide transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide:proton symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptide:proton symporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables proton transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tripeptide transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tripeptide transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in dipeptide transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within dipeptide transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oligopeptide transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peptide transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within proton transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within tripeptide transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dipeptide/tripeptide:H(+) symporter DtpC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4354954..4356411 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418554.1 dipeptide/tripeptide:H(+) symporter DtpC [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418554.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A377B7L0
      Conserved Domains (1) summary
      cl28910
      Location:2 → 475
      MFS; Major Facilitator Superfamily
    Nucleotide Protein
    Heading Accession and Version

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