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    orn oligoribonuclease [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948675, updated on 3-Dec-2024

    Summary

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    Official Symbol
    orn
    Official Full Name
    oligoribonuclease
    Primary source
    ECOCYC:G7842
    Locus tag
    b4162
    See related
    ASAP:ABE-0013631
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4158; yjeR
    Summary
    orn has been shown to be an essential gene (Ghosh, 1999; Baba, 2007). orn has been misclassified as a non-essential gene based the presence of insertions in a on global mutagenesis (Gerdes, 2003). [More information is available at EcoGene: EG12480]. Oligoribonuclease (Orn) is a processive 3'-to-5' exoribonuclease specific for short oligoribonucleotides . [More information is available at EcoCyc: G7842].
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    Genomic context

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    Sequence:
    NC_000913.3 (4391604..4392149)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene phosphatidylserine decarboxylase proenzyme Neighboring gene ribosome small subunit-dependent GTPase A Neighboring gene tRNA-Gly Neighboring gene tRNA-Gly

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Purification and crystallization of Escherichia coli oligoribonuclease. Fiedler TJ, et al. Acta Crystallogr D Biol Crystallogr, 2004 Apr. PMID 15039570
    2. A novel oligoribonuclease of Escherichia coli. II. Mechanism of action. Datta AK, et al. J Biol Chem, 1975 Sep 25. PMID 170260
    3. A novel oligoribonuclease of Escherichia coli. I. Isolation and properties. Niyogi SK, et al. J Biol Chem, 1975 Sep 25. PMID 240824
    4. Oligoribonuclease is distinct from the other known exoribonucleases of Escherichia coli. Yu D, et al. J Bacteriol, 1995 Jul. PMID 7608090, Free PMC Article
    5. Oligoribonuclease is an essential component of the mRNA decay pathway. Ghosh S, et al. Proc Natl Acad Sci U S A, 1999 Apr 13. PMID 10200269, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The expression in E. coli of orn and homologues from Mycobacterium smegmatis and human, and large-scale purification of the three enzymes, is reported.
      Title: Hydrolysis of the 5'-p-nitrophenyl ester of TMP by oligoribonucleases (ORN) from Escherichia coli, Mycobacterium smegmatis, and human.
    2. N-terminus verified by Edman degradation on mature peptide
      Title: Oligoribonuclease is encoded by a highly conserved gene in the 3'-5' exonuclease superfamily.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 3'-5'-RNA exonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3'-5'-RNA exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA exonuclease activity, producing 5'-phosphomonoesters IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oligoribonucleotidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables single-stranded DNA 3'-5' DNA exonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within RNA catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    oligoribonuclease
    NP_418586.4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4391604..4392149
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418586.4 oligoribonuclease [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418586.4

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A418GN53, A0A6M9X3D4
      Conserved Domains (1) summary
      PRK05359
      Location:4 → 181
      PRK05359; oligoribonuclease; Provisional
    Nucleotide Protein
    Heading Accession and Version

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