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    aidB putative acyl-CoA dehydrogenase AidB [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948710, updated on 17-Dec-2024

    Summary

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    Official Symbol
    aidB
    Official Full Name
    putative acyl-CoA dehydrogenase AidB
    Primary source
    ECOCYC:EG11811
    Locus tag
    b4187
    See related
    ASAP:ABE-0013701
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4183
    Summary
    Induced by anaerobiosis and acetate. [More information is available at EcoGene: EG11811]. AidB is involved in the adaptive DNA-repair response of Escherichia coli to alkylating agents. [More information is available at EcoCyc: EG11811].
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    Genomic context

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    Sequence:
    NC_000913.3 (4414275..4415900)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF1190 domain-containing protein YjfM Neighboring gene putative acid--amine ligase YjfC Neighboring gene protease activator YjfN Neighboring gene DUF1471 domain-containing putative lipoprotein BsmA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Escherichia coli alkylation response protein AidB is a redox partner of flavodoxin and binds RNA and acyl carrier protein. Mulrooney SB, et al. Arch Biochem Biophys, 2011 Sep 15. PMID 21782785, Free PMC Article
    2. Induction of the alkylation-inducible aidB gene of Escherichia coli by anaerobiosis. Volkert MR, et al. J Bacteriol, 1989 Feb. PMID 2492508, Free PMC Article
    3. Hydrogen peroxide induces protection against N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) effects in Escherichia coli. Asad LM, et al. Mutat Res, 1997 Mar 12. PMID 9088346
    4. Identification and expression of the SOS response, aidB-like, gene in the marine sponge Geodia cydonium: implication for the phylogenetic relationships of metazoan acyl-CoA dehydrogenases and acyl-CoA oxidases. Krasko A, et al. J Mol Evol, 1998 Sep. PMID 9732461
    5. Nucleotides from -16 to -12 determine specific promoter recognition by bacterial sigmaS-RNA polymerase. Lacour S, et al. J Biol Chem, 2003 Sep 26. PMID 12853450

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AidB exhibits several discrepancies from ACADs that suggest a novel catalytic mechanism distinct from that of the ACAD family enzymes.
      Title: Electrochemical characterization of Escherichia coli adaptive response protein AidB.
    2. AidB was found to bind to RNA, raising the prospect that the protein may have a role in protection of RNA from chemical alkylation.
      Title: The Escherichia coli alkylation response protein AidB is a redox partner of flavodoxin and binds RNA and acyl carrier protein.
    3. The N-terminal region, comprising the first 439 amino acids possesses dehydrogenase activity, while its C-terminal domain, corresponding to residues 440 to 541 displays DNA binding activity and can negatively regulate the expression of its own gene.
      Title: Specific DNA binding and regulation of its own expression by the AidB protein in Escherichia coli.
    4. a 1.7-A crystal structure of AidB, which bears superficial resemblance to the acyl-CoA dehydrogenase superfamily of flavoproteins
      Title: Structure and DNA binding of alkylation response protein AidB.
    5. AidB is shown to possess flavin adenine dinucleotide (FAD), low levels of isovaleryl-coenzyme A (CoA) dehydrogenase activity, and ability to bind DNA, and is predicted to catalyze the direct repair of alkylated DNA
      Title: The AidB component of the Escherichia coli adaptive response to alkylating agents is a flavin-containing, DNA-binding protein.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 3-methylbutanoyl-CoA dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyl-CoA dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acyl-CoA dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of DNA-templated transcription IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative acyl-CoA dehydrogenase AidB
    NP_418608.6

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4414275..4415900
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418608.6 putative acyl-CoA dehydrogenase AidB [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418608.6

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7E9R1, A0A9P2IBG5
      Conserved Domains (1) summary
      PRK11561
      Location:1 → 538
      PRK11561; isovaleryl CoA dehydrogenase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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