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    ulaA L-ascorbate specific PTS enzyme IIC component [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948717, updated on 17-Dec-2024

    Summary

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    Official Symbol
    ulaA
    Official Full Name
    L-ascorbate specific PTS enzyme IIC component
    Primary source
    ECOCYC:G7856
    Locus tag
    b4193
    See related
    ASAP:ABE-0013723
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4189; sgaT; yjfS
    Summary
    The ula divergon is comprised of the two divergent ulaGR and ulaABCDEF operons. [More information is available at EcoGene: EG12493]. UlaA is required for the ability to utilize L-ascorbate as the carbon source under anaerobic growth conditions . [More information is available at EcoCyc: G7856].
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    Genomic context

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    Sequence:
    NC_000913.3 (4419980..4421377)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene carboxylesterase Neighboring gene DNA-binding transcriptional repressor UlaR Neighboring gene L-ascorbate-6-phosphate lactonase Neighboring gene L-ascorbate specific PTS enzyme IIB component Neighboring gene L-ascorbate specific PTS enzyme IIA component

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The V-motifs facilitate the substrate capturing step of the PTS elevator mechanism. Vastermark A, et al. J Struct Biol, 2016 Dec. PMID 27720943, Free PMC Article
    2. Investigation into the resistance of lactoperoxidase tolerant Escherichia coli mutants to different forms of oxidative stress. De Spiegeleer P, et al. FEMS Microbiol Lett, 2005 Nov 15. PMID 16209909
    3. Bioinformatic analyses of the bacterial L-ascorbate phosphotransferase system permease family. Hvorup R, et al. J Mol Microbiol Biotechnol, 2003. PMID 15153772
    4. Is the ribulose monophosphate pathway widely distributed in bacteria? Reizer J, et al. Microbiology (Reading), 1997 Aug. PMID 9274005
    5. The gene yjfQ encodes the repressor of the yjfR-X regulon (ula), which is involved in L-ascorbate metabolism in Escherichia coli. Campos E, et al. J Bacteriol, 2002 Nov. PMID 12374842, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-phosphocysteine-L-ascorbate-phosphotransferase system transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within L-ascorbic acid transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within L-ascorbic acid transmembrane transport IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in L-ascorbic acid transmembrane transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within phosphoenolpyruvate-dependent sugar phosphotransferase system IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phosphoenolpyruvate-dependent sugar phosphotransferase system IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphoenolpyruvate-dependent sugar phosphotransferase system NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transmembrane transporter complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    L-ascorbate specific PTS enzyme IIC component
    NP_418614.4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4419980..4421377
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418614.4 L-ascorbate specific PTS enzyme IIC component [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418614.4

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376RS91, A0A8T5YLU5
      Conserved Domains (1) summary
      PRK09548
      Location:1 → 462
      PRK09548; PTS ascorbate-specific subunit IIBC
    Nucleotide Protein
    Heading Accession and Version

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