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    fbp fructose-1,6-bisphosphatase 1 [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948753, updated on 3-Dec-2024

    Summary

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    Official Symbol
    fbp
    Official Full Name
    fructose-1,6-bisphosphatase 1
    Primary source
    ECOCYC:EG10283
    Locus tag
    b4232
    See related
    ASAP:ABE-0013842
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4227; fdp
    Summary
    Fructose-1,6-bisphosphatase catalyzes the conversion of fructose-1,6-bisphosphate to fructose-6-phosphate in the gluconeogenesis pathway. [More information is available at EcoCyc: EG10283].
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    Genomic context

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    Sequence:
    NC_000913.3 (4454611..4455609, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene galactofuranose ABC transporter putative ATP binding subunit Neighboring gene galactofuranose ABC transporter putative membrane subunit YtfT Neighboring gene galactofuranose ABC transporter putative membrane subunit YjtF Neighboring gene UDP-N-acetylmuramate--L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate ligase Neighboring gene putative ribosome biogenesis factor YjgA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Amino acid sequence homology among fructose-1,6-bisphosphatases. Marcus F, et al. Biochem Biophys Res Commun, 1986 Mar 13. PMID 3008716
    2. Inhibition of Escherichia coli fructose-1,6-bisphosphatase by fructose 2,6-bisphosphate. Marcus F, et al. Biochem Biophys Res Commun, 1984 Mar 30. PMID 6324777
    3. Fructose bisphosphatase of Escherichia coli: cloning of the structural gene (fbp) and preparation of a chromosomal deletion. Sedivy JM, et al. J Bacteriol, 1984 Jun. PMID 6327623, Free PMC Article
    4. Fructose bisphosphatase from Escherichia coli. Purification and characterization. Babul J, et al. Arch Biochem Biophys, 1983 Sep. PMID 6312898
    5. Purification, kinetic studies, and homology model of Escherichia coli fructose-1,6-bisphosphatase. Kelley-Loughnane N, et al. Biochim Biophys Acta, 2002 Jan 31. PMID 11825604

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. analysis of inhibited fructose-1,6-bisphosphatase from Escherichia coli
      Title: Structure of inhibited fructose-1,6-bisphosphatase from Escherichia coli: distinct allosteric inhibition sites for AMP and glucose 6-phosphate and the characterization of a gluconeogenic switch.
    2. suggest a new mechanism of regulation in the FBPase enzyme family: anionic ligands, most likely phosphoenolpyruvate, bind to allosteric activator sites, which in turn stabilize a tetramer and a polypeptide fold that obstructs AMP binding
      Title: Novel allosteric activation site in Escherichia coli fructose-1,6-bisphosphatase.
    3. conformational changes in two helices due to the binding of AMP
      Title: R-state AMP complex reveals initial steps of the quaternary transition of fructose-1,6-bisphosphatase.
    4. analysis of activated fructose-1,6-bisphosphatase from Escherichia coli shows a mechanism of feed-forward activation in bacterial central metabolism
      Title: Structures of activated fructose-1,6-bisphosphatase from Escherichia coli. Coordinate regulation of bacterial metabolism and the conservation of the R-state.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables fructose 1,6-bisphosphate 1-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fructose 1,6-bisphosphate 1-phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables fructose 1,6-bisphosphate 1-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fructose 1,6-bisphosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fructose 6-phosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fructose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in gluconeogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in gluconeogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within gluconeogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    fructose-1,6-bisphosphatase 1
    NP_418653.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4454611..4455609 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418653.1 fructose-1,6-bisphosphatase 1 [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418653.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A828NX89
      Conserved Domains (1) summary
      PRK09293
      Location:1 → 330
      PRK09293; class 1 fructose-bisphosphatase
    Nucleotide Protein
    Heading Accession and Version

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