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    mraY phospho-N-acetylmuramoyl-pentapeptide-transferase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 944814, updated on 3-Dec-2024

    Summary

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    Official Symbol
    mraY
    Official Full Name
    phospho-N-acetylmuramoyl-pentapeptide-transferase
    Primary source
    ECOCYC:EG10604
    Locus tag
    b0087
    See related
    ASAP:ABE-0000316
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0088; murX
    Summary
    The aspartic acid residues DD115, D116, and D267 are necessary for catalysis. [More information is available at EcoGene: EG10604].
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    Genomic context

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    Sequence:
    NC_000913.3 (96002..97084)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene peptidoglycan DD-transpeptidase FtsI Neighboring gene ncRNA Neighboring gene UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase Neighboring gene D-alanyl-D-alanine-adding enzyme Neighboring gene UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase Neighboring gene peptidoglycan glycosyltransferase FtsW Neighboring gene N-acetylglucosaminyl transferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phospho-N-acetylmuramoyl-pentapeptide-transferase of Escherichia coli K12. Properties of the membrane-bound and the extracted and partially purified enzyme. Geis A, et al. Biochim Biophys Acta, 1978 Dec 8. PMID 215212
    2. The Escherichia coli mraY gene encoding UDP-N-acetylmuramoyl-pentapeptide: undecaprenyl-phosphate phospho-N-acetylmuramoyl-pentapeptide transferase. Ikeda M, et al. J Bacteriol, 1991 Feb. PMID 1846850, Free PMC Article
    3. Modes of action of tunicamycin, liposidomycin B, and mureidomycin A: inhibition of phospho-N-acetylmuramyl-pentapeptide translocase from Escherichia coli. Brandish PE, et al. Antimicrob Agents Chemother, 1996 Jul. PMID 8807054, Free PMC Article
    4. mraY is an essential gene for cell growth in Escherichia coli. Boyle DS, et al. J Bacteriol, 1998 Dec. PMID 9829961, Free PMC Article
    5. Genetic analysis of MraY inhibition by the phiX174 protein E. Zheng Y, et al. Genetics, 2008 Nov. PMID 18791230, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. It is postulated that the involvement of MurG in the peptidoglycan synthesis concurs with two complexes, one implicated in cell elongation and the other in division.
      Title: The essential peptidoglycan glycosyltransferase MurG forms a complex with proteins involved in lateral envelope growth as well as with proteins involved in cell division in Escherichia coli.
    2. results imply that the interaction of bacteriophage phiX174 lysis protein E with MraY is not at the MraY active site, and suggest that a protein-protein interaction is formed between E of PhiX174 and MraY at a site within the transmembrane region
      Title: Interaction of the transmembrane domain of lysis protein E from bacteriophage phiX174 with bacterial translocase MraY and peptidyl-prolyl isomerase SlyD.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospho-N-acetylmuramoyl-pentapeptide-transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phospho-N-acetylmuramoyl-pentapeptide-transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phospho-N-acetylmuramoyl-pentapeptide-transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphotransferase activity, for other substituted phosphate groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell wall macromolecule biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell wall organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell wall organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peptidoglycan biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell shape IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    phospho-N-acetylmuramoyl-pentapeptide-transferase
    NP_414629.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      96002..97084
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414629.1 phospho-N-acetylmuramoyl-pentapeptide-transferase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414629.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A775UT54
      Conserved Domains (1) summary
      PRK00108
      Location:16 → 360
      mraY; phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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