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    murC UDP-N-acetylmuramate--L-alanine ligase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946153, updated on 3-Dec-2024

    Summary

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    Official Symbol
    murC
    Official Full Name
    UDP-N-acetylmuramate--L-alanine ligase
    Primary source
    ECOCYC:EG10619
    Locus tag
    b0091
    See related
    ASAP:ABE-0000324
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0092
    Summary
    PDB: [More information is available at EcoGene: EG10619].
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    Genomic context

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    Sequence:
    NC_000913.3 (100765..102240)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase Neighboring gene peptidoglycan glycosyltransferase FtsW Neighboring gene N-acetylglucosaminyl transferase Neighboring gene D-alanine--D-alanine ligase B Neighboring gene cell division protein FtsQ Neighboring gene cell division protein FtsA Neighboring gene cell division protein FtsZ

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of an inhibitor of the MurC enzyme, which catalyzes an essential step in the peptidoglycan precursor synthesis pathway. Zawadzke LE, et al. Assay Drug Dev Technol, 2008 Feb. PMID 18315498
    2. Study of the overproduced uridine-diphosphate-N-acetylmuramate:L-alanine ligase from Escherichia coli. Liger D, et al. Microb Drug Resist, 1996 Spring. PMID 9158719
    3. Invariant amino acids in the Mur peptide synthetases of bacterial peptidoglycan synthesis and their modification by site-directed mutagenesis in the UDP-MurNAc:L-alanine ligase from Escherichia coli. Bouhss A, et al. Biochemistry, 1997 Sep 30. PMID 9305945
    4. Structural studies of Escherichia coli UDP-N-acetylmuramate:L-alanine ligase. Jin H, et al. Biochemistry, 1996 Feb 6. PMID 8634272
    5. Biochemical evidence for the formation of a covalent acyl-phosphate linkage between UDP-N-acetylmuramate and ATP in the Escherichia coli UDP-N-acetylmuramate:L-alanine ligase-catalyzed reaction. Falk PJ, et al. Biochemistry, 1996 Feb 6. PMID 8634271

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on complete protein
      Title: Over-production, purification and properties of the uridine-diphosphate-N-acetylmuramate:L-alanine ligase from Escherichia coli.
    2. The crystal structure of Escherichia coli UDP-N-acetylmuramoyl:L-alanine ligase (MurC) has been determined to 2.6 A resolution.
      Title: Structure of Escherichia coli UDP-N-acetylmuramoyl:L-alanine ligase (MurC).
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables UDP-N-acetylmuramate-L-alanine ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables UDP-N-acetylmuramate-L-alanine ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acid-amino acid ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell wall organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peptidoglycan biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within peptidoglycan biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell shape IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    UDP-N-acetylmuramate--L-alanine ligase
    NP_414633.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      100765..102240
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414633.1 UDP-N-acetylmuramate--L-alanine ligase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414633.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8T5ZGV2, A0A8T6PMU6
      Conserved Domains (1) summary
      PRK00421
      Location:13 → 484
      murC; UDP-N-acetylmuramate--L-alanine ligase; Provisional
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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