proS proline--tRNA ligase [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

Official Symbol: proS
Official Full Name: proline--tRNA ligase
Primary source: ECOCYC:EG10770
Locus tag: b0194
See related: ASAP:ABE-0000657
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: drp; drpA; ECK0194
Summary: An insertion domain (248-393) in ProS is homologous to YeaK and YbaK. [More information is available at EcoGene: EG10770]. Prolyl-tRNA synthetase (ProRS) is a member of the family of aminoacyl-tRNA synthetases, which interpret the genetic code by covalently linking amino acids to their specific tRNA molecules. [More information is available at EcoCyc: EG10770].
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NC_000913.3 Genomic Context describing neighboring genes

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Effects of Distal Mutations on Prolyl-Adenylate Formation of Escherichia coli Prolyl-tRNA Synthetase.
Title: Effects of Distal Mutations on Prolyl-Adenylate Formation of Escherichia coli Prolyl-tRNA Synthetase.
Multiple pathways exist between the aminoacylation and editing domains of E. coli ProRS that maintain the dynamic coupling essential for enzyme function.
Title: Multiple pathways promote dynamical coupling between catalytic domains in Escherichia coli prolyl-tRNA synthetase.
pre- and post-transfer editing pathways work in concert to ensure accurate aminoacylation by ProRS
Title: Transfer RNA modulates the editing mechanism used by class II prolyl-tRNA synthetase.
N-terminus verified by Edman degradation on complete protein
Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables Ala-tRNA(Pro) hydrolase activity	IDA Inferred from Direct Assay more info	PubMed
enables aminoacyl-tRNA editing activity	IEA Inferred from Electronic Annotation more info
enables aminoacyl-tRNA ligase activity	IEA Inferred from Electronic Annotation more info
enables proline-tRNA ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables proline-tRNA ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables proline-tRNA ligase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in aminoacyl-tRNA metabolism involved in translational fidelity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in prolyl-tRNA aminoacylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in prolyl-tRNA aminoacylation	IEA Inferred from Electronic Annotation more info
involved_in prolyl-tRNA aminoacylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tRNA aminoacylation for protein translation	IEA Inferred from Electronic Annotation more info
involved_in translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	HDA more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed

NP_414736.1

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