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    ddlA D-alanine--D-alanine ligase A [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945313, updated on 3-Dec-2024

    Summary

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    Official Symbol
    ddlA
    Official Full Name
    D-alanine--D-alanine ligase A
    Primary source
    ECOCYC:EG10213
    Locus tag
    b0381
    See related
    ASAP:ABE-0001309
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0376
    Summary
    The subunit structure is not known at this time. [More information is available at EcoCyc: EG10213].
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    Genomic context

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    Sequence:
    NC_000913.3 (399829..400923, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF2755 domain-containing inner membrane protein YaiY Neighboring gene DUF2754 domain-containing protein YaiZ Neighboring gene anti-adaptor protein IraP Neighboring gene alkaline phosphatase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A de novo designed inhibitor of D-Ala-D-Ala ligase from E. coli. Besong GE, et al. Angew Chem Int Ed Engl, 2005 Oct 7. PMID 16158456
    2. Gain of D-alanyl-D-lactate or D-lactyl-D-alanine synthetase activities in three active-site mutants of the Escherichia coli D-alanyl-D-alanine ligase B. Park IS, et al. Biochemistry, 1996 Aug 13. PMID 8756703
    3. D-alanine: D-alanine ligase of Escherichia coli. Expression, purification and inhibitory studies on the cloned enzyme. al-Bar OA, et al. Biochem J, 1992 Mar 15. PMID 1554356, Free PMC Article
    4. Existence of two D-alanine:D-alanine ligases in Escherichia coli: cloning and sequencing of the ddlA gene and purification and characterization of the DdlA and DdlB enzymes. Zawadzke LE, et al. Biochemistry, 1991 Feb 12. PMID 1993184
    5. Screen for genes involved in radiation survival of Escherichia coli and construction of a reference database. Sargentini NJ, et al. Mutat Res, 2016 Nov-Dec. PMID 27718375

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables D-alanine-D-alanine ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables D-alanine-D-alanine ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables D-alanine-D-alanine ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell wall organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peptidoglycan biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peptidoglycan biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell shape IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to X-ray IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    D-alanine--D-alanine ligase A
    NP_414915.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      399829..400923 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414915.1 D-alanine--D-alanine ligase A [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414915.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376FTM7, A0A376MBL1
      Conserved Domains (1) summary
      PRK01966
      Location:1 → 352
      ddl; D-alanine--D-alanine ligase
    Nucleotide Protein
    Heading Accession and Version

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