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    acrR DNA-binding transcriptional repressor AcrR [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945516, updated on 3-Dec-2024

    Summary

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    Official Symbol
    acrR
    Official Full Name
    DNA-binding transcriptional repressor AcrR
    Primary source
    ECOCYC:EG12116
    Locus tag
    b0464
    See related
    ASAP:ABE-0001608
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0458; ybaH
    Summary
    TetR family. [More information is available at EcoGene: EG12116]. The "acriflavine resistance regulator", AcrR, regulates the expression of genes involved in multidrug transport and is classified in the nodulation-resistance division family . [More information is available at EcoCyc: EG12116].
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    Genomic context

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    Sequence:
    NC_000913.3 (485761..486408)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene multidrug efflux pump RND permease AcrB Neighboring gene multidrug efflux pump membrane fusion lipoprotein AcrA Neighboring gene potassium dependent, small conductance mechanosensitive channel Neighboring gene DUF2496 domain-containing protein YbaM

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic characterization of phenicol-resistant Escherichia coli and role of wild-type repressor/regulator gene (acrR) on phenicol resistance. Yaqoob M, et al. Folia Microbiol (Praha), 2018 Jul. PMID 29307119
    2. Potential Swimming Motility Variation by AcrR in Escherichia coli. Kim YJ, et al. J Microbiol Biotechnol, 2016 Oct 28. PMID 27558437
    3. Structures of AcrR and CmeR: insight into the mechanisms of transcriptional repression and multi-drug recognition in the TetR family of regulators. Routh MD, et al. Biochim Biophys Acta, 2009 May. PMID 19130905, Free PMC Article
    4. Conformational change of the AcrR regulator reveals a possible mechanism of induction. Gu R, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2008 Jul 1. PMID 18607081, Free PMC Article
    5. Characterization of the multidrug efflux regulator AcrR from Escherichia coli. Su CC, et al. Biochem Biophys Res Commun, 2007 Sep 14. PMID 17644067, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mutations in AcrR and RNA Polymerase Confer High-Level Resistance to Psoralen-UVA Irradiation.
      Title: Mutations in AcrR and RNA Polymerase Confer High-Level Resistance to Psoralen-UVA Irradiation.
    2. Mutations of AcrR protein in chloramphenicol resistant Ecoli, isolated from diseased chickens, cause the overexpression of AcrA protein of the AcrAB multidrug efflux pump. Complementation with a plasmid-borne wild-type acrR gene reduces the expression level of AcrA protein in the mutants and partially restored antibiotic susceptibility.
      Title: Genetic characterization of phenicol-resistant Escherichia coli and role of wild-type repressor/regulator gene (acrR) on phenicol resistance.
    3. Studied the genome-wide target genes of E. coli AcrR in a DeltaacrR mutant strain by microarray analysis. Motility assays revealed that AcrR modulates swimming motility, but not swarming.
      Title: Potential Swimming Motility Variation by AcrR in Escherichia coli.
    4. PCR analysis of RNA from the wild-type, DeltaacrR, and acrR (+) strains showed that AcrR represses the transcription of marRAB and soxRS, and its own gene cluster, acrRAB.
      Title: Overproduction of AcrR increases organic solvent tolerance mediated by modulation of SoxS regulon in Escherichia coli.
    5. A palindrome operator sequence that binds the multidrug efflux regulator AcrR was determined.
      Title: Characterization of the multidrug efflux regulator AcrR from Escherichia coli.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables toxic substance binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription cis-regulatory region binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within response to xenobiotic stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA-binding transcriptional repressor AcrR

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      485761..486408
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414997.1 DNA-binding transcriptional repressor AcrR [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414997.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7JY64
      Conserved Domains (1) summary
      PRK10668
      Location:1 → 215
      PRK10668; DNA-binding transcriptional repressor AcrR; Provisional
    Nucleotide Protein
    Heading Accession and Version

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