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    fldA flavodoxin 1 [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945293, updated on 3-Dec-2024

    Summary

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    Official Symbol
    fldA
    Official Full Name
    flavodoxin 1
    Primary source
    ECOCYC:EG10318
    Locus tag
    b0684
    See related
    ASAP:ABE-0002332
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0672
    Summary
    Essential gene. [More information is available at EcoGene: EG10318]. Flavodoxins are small, acidic electron transfer proteins which contain FMN as a prosthetic group. [More information is available at EcoCyc: EG10318].
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    Genomic context

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    Sequence:
    NC_000913.3 (710935..711465, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene lipoprotein ChiQ Neighboring gene DNA-binding transcriptional dual regulator Fur Neighboring gene RyhB-regulated fur leader peptide Neighboring gene ribbon-helix-helix domain-containing protein YbfE Neighboring gene esterase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Flavodoxin is required for the activation of the anaerobic ribonucleotide reductase. Bianchi V, et al. Biochem Biophys Res Commun, 1993 Dec 15. PMID 8267617
    2. The interaction of NADPH-P450 reductase with P450: an electrochemical study of the role of the flavin mononucleotide-binding domain. Estabrook RW, et al. Arch Biochem Biophys, 1996 Sep 1. PMID 8806785
    3. NMR assignments, secondary structure and hydration of oxidized Escherichia coli flavodoxin. Ponstingl H, et al. Eur J Biochem, 1997 Mar 1. PMID 9119004
    4. A flavodoxin that is required for enzyme activation: the structure of oxidized flavodoxin from Escherichia coli at 1.8 A resolution. Hoover DM, et al. Protein Sci, 1997 Dec. PMID 9416602, Free PMC Article
    5. Flavodoxin is required for conversion of dethiobiotin to biotin in Escherichia coli. Ifuku O, et al. Eur J Biochem, 1994 Aug 15. PMID 8076639

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on mature peptide
      Title: Flavodoxin and NADPH-flavodoxin reductase from Escherichia coli support bovine cytochrome P450c17 hydroxylase activities.
    2. The essential role for flavodoxin I in E. coli is in the MEP pathway for isoprenoid biosynthesis.
      Title: fldA is an essential gene required in the 2-C-methyl-D-erythritol 4-phosphate pathway for isoprenoid biosynthesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables FMN binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables electron transfer activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    flavodoxin 1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      710935..711465 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415210.1 flavodoxin 1 [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415210.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376MCQ1, A0AAN5UE24
      Conserved Domains (1) summary
      PRK09267
      Location:1 → 170
      PRK09267; flavodoxin FldA; Validated
    Nucleotide Protein
    Heading Accession and Version

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