kdpE DNA-binding transcriptional activator KdpE [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

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Official Symbol: kdpE
Official Full Name: DNA-binding transcriptional activator KdpE
Primary source: ECOCYC:EG10517
Locus tag: b0694
See related: ASAP:ABE-0002366
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK0682
Summary: KdpD phosphatase activity may be inhibited by turgor pressure, leading to an accumulation of phospho-KdpE and activation of kdpFABC transcription. [More information is available at EcoGene: EG10517]. The protein belongs to the two-component family. [More information is available at EcoCyc: EG10517].
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Genomic context

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Sequence:: NC_000913.3 (721056..721733, complement)

NC_000913.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Structural insights into the signal transduction mechanism of the K(+)-sensing two-component system KdpDE.
Title: Structural insights into the signal transduction mechanism of the K(+)-sensing two-component system KdpDE.
The structure of the KdpE-DNA complex reveals a novel heterodomain interface.
Title: An asymmetric heterodomain interface stabilizes a response regulator-DNA complex.
The deletion of cra and kdpE resulted in the ablation of attaching and effacing lesions.
Title: Virulence meets metabolism: Cra and KdpE gene regulation in enterohemorrhagic Escherichia coli.
Structure-function studies of DNA binding domain of response regulator KdpE reveals equal affinity interactions at DNA half-sites.
Title: Structure-function studies of DNA binding domain of response regulator KdpE reveals equal affinity interactions at DNA half-sites.
The response regulator KdpE receives the phosphoryl group from KdpD and induces kdpFABC transcription.
Title: The complexity of the 'simple' two-component system KdpD/KdpE in Escherichia coli.
The universal stress protein UspC scaffolds the KdpD/KdpE signaling cascade of Escherichia coli under salt stress
Title: The universal stress protein UspC scaffolds the KdpD/KdpE signaling cascade of Escherichia coli under salt stress.
N-terminus verified by Edman degradation on complete protein
Title: Phosphotransfer signal transduction between two regulatory factors involved in the osmoregulated kdp operon in Escherichia coli.
the X-ray crystal structures of the regulatory domains of response regulators TorR (1.8 A), Ca(2+)-bound KdpE (2.0 A), and Mg(2+)/BeF(3)(-)-bound KdpE (2.2 A), both members of the OmpR/ PhoB subfamily from Escherichia coli
Title: A common dimerization interface in bacterial response regulators KdpE and TorR.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by EcoCyc

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphorelay response regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription cis-regulatory region binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in phosphorelay signal transduction system	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-DNA complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: DNA-binding transcriptional activator KdpE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_000913.3 Reference assembly

Range

721056..721733 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NP_415222.1 DNA-binding transcriptional activator KdpE [Escherichia coli str. K-12 substr. MG1655]

See identical proteins and their annotated locations for NP_415222.1

Status: PROVISIONAL

UniProtKB/TrEMBL

A0A376FMJ7

Conserved Domains (1) summary

PRK10529
Location:1 → 224

PRK10529; DNA-binding transcriptional activator KdpE; Provisional