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    kdpB K(+) transporting P-type ATPase subunit KdpB [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947450, updated on 3-Dec-2024

    Summary

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    Official Symbol
    kdpB
    Official Full Name
    K(+) transporting P-type ATPase subunit KdpB
    Primary source
    ECOCYC:EG10514
    Locus tag
    b0697
    See related
    ASAP:ABE-0002376
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0685; kac
    Summary
    HAD superfamily. [More information is available at EcoGene: EG10514]. The kdpFABC genes encode an ATP-dependent high affinity P-Type ATPase potassium ion transporter . [More information is available at EcoCyc: EG10514].
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    Genomic context

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    Sequence:
    NC_000913.3 (724988..727036, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional activator KdpE Neighboring gene sensor histidine kinase KdpD Neighboring gene K(+) transporting P-type ATPase subunit KdpC Neighboring gene K(+) transporting P-type ATPase subunit KdpA Neighboring gene K(+) transporting P-type ATPase subunit KdpF

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutational analysis of charged residues in the putative KdpB-TM5 domain of the Kdp-ATPase of Escherichia coli. Bramkamp M, et al. Ann N Y Acad Sci, 2003 Apr. PMID 12763849
    2. 1H, 13C and 15N resonance assignment of the nucleotide binding domain of KdpB from Escherichia coli. Haupt M, et al. J Biomol NMR, 2004 Jul. PMID 15213457
    3. Functional modules of KdpB, the catalytic subunit of the Kdp-ATPase from Escherichia coli. Bramkamp M, et al. Biochemistry, 2004 Sep 28. PMID 15379567
    4. The conserved dipole in transmembrane helix 5 of KdpB in the Escherichia coli KdpFABC P-type ATPase is crucial for coupling and the electrogenic K+-translocation step. Becker D, et al. Biochemistry, 2007 Dec 4. PMID 17994765
    5. The holo-form of the nucleotide binding domain of the KdpFABC complex from Escherichia coli reveals a new binding mode. Haupt M, et al. J Biol Chem, 2006 Apr 7. PMID 16354672

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structural basis for potassium transport in prokaryotes by KdpFABC.
      Title: Structural basis for potassium transport in prokaryotes by KdpFABC.
    2. Data indicate that KdpFABC P-type ATPase activity could be stimulated not only by the presence of the transported K+ ions in a pH-dependent manner but also, to a significantly lesser extent, by H+ and Na+.
      Title: Mechanistic analysis of the pump cycle of the KdpFABC P-type ATPase.
    3. Data show that the increase in the anionic lipid composition enhances the expression rate of the kdpFABC operon.
      Title: Influence of K+-dependent membrane lipid composition on the expression of the kdpFABC operon in Escherichia coli.
    4. review features of P-type ATPases are attributed to the KdpB subunit
      Title: The K+-translocating KdpFABC complex from Escherichia coli: a P-type ATPase with unique features.
    5. NMR structure of the AMP-PNP-bound nucleotide binding domain KdpBN of the Escherichia coli Kdp-ATPase at high resolution
      Title: The holo-form of the nucleotide binding domain of the KdpFABC complex from Escherichia coli reveals a new binding mode.
    6. A new transport model for Kdp-ATPase is presented, in which highly conserved charged residues Asp583 and Lys586 of the KdpB subunit may play a role in the gating mechanism of the complex.
      Title: Single amino acid substitution in the putative transmembrane helix V in KdpB of the KdpFABC complex of Escherichia coli uncouples ATPase activity and ion transport.
    7. NMR assignment of the nucleotide binding domain of KdpB from Escherichia coli
      Title: 1H, 13C and 15N resonance assignment of the nucleotide binding domain of KdpB from Escherichia coli.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables P-type ion transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables P-type potassium transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables P-type potassium transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables P-type potassium transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables P-type potassium transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within monoatomic cation transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within potassium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within potassium ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in potassium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within potassium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    part_of potassium ion-transporting ATPase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of potassium:proton antiporter complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    K(+) transporting P-type ATPase subunit KdpB
    NP_415225.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      724988..727036 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415225.1 K(+) transporting P-type ATPase subunit KdpB [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415225.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0AAI9GXI9
      Conserved Domains (1) summary
      PRK01122
      Location:1 → 682
      PRK01122; potassium-transporting ATPase subunit KdpB
    Nucleotide Protein
    Heading Accession and Version

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