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    appC cytochrome bd-II subunit 1 [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945585, updated on 3-Dec-2024

    Summary

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    Official Symbol
    appC
    Official Full Name
    cytochrome bd-II subunit 1
    Primary source
    ECOCYC:EG11380
    Locus tag
    b0978
    See related
    ASAP:ABE-0003300
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    cbdA; cyxA; ECK0969
    Summary
    EvgAS regulon. [More information is available at EcoGene: EG11380].
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    Genomic context

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    Sequence:
    NC_000913.3 (1037740..1039284)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene hydrogenase 1 cytochrome b subunit Neighboring gene putative hydrogenase 1 maturation protease HyaD Neighboring gene putative HyaA chaperone Neighboring gene protein HyaF Neighboring gene cytochrome bd-II subunit 2 Neighboring gene cytochrome bd-II accessory subunit AppX

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Preparations of Terminal Oxidase Cytochrome bd-II Isolated from Escherichia coli Reveal Significant Hydrogen Peroxide Scavenging Activity. Forte E, et al. Biochemistry (Mosc), 2022 Aug. PMID 36171653
    2. Aerobic respiratory chain of Escherichia coli is not allowed to work in fully uncoupled mode. Borisov VB, et al. Proc Natl Acad Sci U S A, 2011 Oct 18. PMID 21987791, Free PMC Article
    3. Cytochrome bd oxidase and nitric oxide: from reaction mechanisms to bacterial physiology. Giuffrè A, et al. FEBS Lett, 2012 Mar 9. PMID 21821033
    4. Respiration of Escherichia coli can be fully uncoupled via the nonelectrogenic terminal cytochrome bd-II oxidase. Bekker M, et al. J Bacteriol, 2009 Sep. PMID 19542282, Free PMC Article
    5. Aerobic fermentation of D-glucose by an evolved cytochrome oxidase-deficient Escherichia coli strain. Portnoy VA, et al. Appl Environ Microbiol, 2008 Dec. PMID 18952873, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Preparations of Terminal Oxidase Cytochrome bd-II Isolated from Escherichia coli Reveal Significant Hydrogen Peroxide Scavenging Activity.
      Title: Preparations of Terminal Oxidase Cytochrome bd-II Isolated from Escherichia coli Reveal Significant Hydrogen Peroxide Scavenging Activity.
    2. Studies suggest that the prokaryotic respiratory cytochrome bd quinol oxidase is responsible for both bioenergetic functions and bacterial adaptation to different stress conditions.
      Title: Cytochrome bd oxidase and nitric oxide: from reaction mechanisms to bacterial physiology.
    3. Proposed arrangement of transmembrane helices in subunit I of cytochrome bd quinol oxidase may explain possible roles of conserved hydrophilic residues within the membrane.
      Title: Glutamates 99 and 107 in transmembrane helix III of subunit I of cytochrome bd are critical for binding of the heme b595-d binuclear center and enzyme activity.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables cytochrome bo3 ubiquinol oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables electron transfer activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables electron transfer activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables electron transfer activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heme binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in aerobic electron transport chain IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within aerobic electron transport chain IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in aerobic electron transport chain IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within aerobic electron transport chain IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oxidative phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of cytochrome complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytochrome complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytochrome complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cytochrome bd-II subunit 1
    NP_415497.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1037740..1039284
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415497.1 cytochrome bd-II subunit 1 [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415497.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A1X3JKM6
      Conserved Domains (1) summary
      PRK15035
      Location:1 → 514
      PRK15035; cytochrome bd-II oxidase subunit 1; Provisional
    Nucleotide Protein
    Heading Accession and Version

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