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    bluF blue light- and temperature-regulated antirepressor BluF [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947592, updated on 17-Dec-2024

    Summary

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    Official Symbol
    bluF
    Official Full Name
    blue light- and temperature-regulated antirepressor BluF
    Primary source
    ECOCYC:G6603
    Locus tag
    b1163
    See related
    ASAP:ABE-0003903
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1150; ycgF
    Summary
    YcgF has an N-terminal blue light-responsive FAD-binding BLUF domain. [More information is available at EcoGene: EG13887]. YcgF is a member of the family of blue-light sensing proteins that use FAD (BLUF). [More information is available at EcoCyc: G6603].
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    Genomic context

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    Sequence:
    NC_000913.3 (1214264..1215475, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF1398 domain-containing protein YcgX Neighboring gene DNA-binding transcriptional repressor BluR Neighboring gene putative two-component system connector protein YcgZ Neighboring gene putative two-component system connector protein YmgA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transient dimerization and conformational change of a BLUF protein: YcgF. Nakasone Y, et al. J Am Chem Soc, 2007 Jun 6. PMID 17489591
    2. Analysis of proton wires in the enzyme active site suggests a mechanism of c-di-GMP hydrolysis by the EAL domain phosphodiesterases. Grigorenko BL, et al. Proteins, 2016 Nov. PMID 27479508
    3. AppA, a redox regulator of photosystem formation in Rhodobacter sphaeroides 2.4.1, is a flavoprotein. Identification of a novel fad binding domain. Gomelsky M, et al. J Biol Chem, 1998 Dec 25. PMID 9857073
    4. Purification and initial characterization of a putative blue light-regulated phosphodiesterase from Escherichia coli. Rajagopal S, et al. Photochem Photobiol, 2004 Nov-Dec. PMID 15453820
    5. Influence of a joining helix on the BLUF domain of the YcgF photoreceptor from Escherichia coli. Schroeder C, et al. Chembiochem, 2008 Oct 13. PMID 18792053

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Analysis of proton wires in the enzyme active site suggests a mechanism of c-di-GMP hydrolysis by the EAL domain Blrp (bluF).
      Title: Analysis of proton wires in the enzyme active site suggests a mechanism of c-di-GMP hydrolysis by the EAL domain phosphodiesterases.
    2. Data identified the BluR binding site in the ycgZ promoter and observed that BluR also has residual affinity for the MlrA-dependent csgD promoter.
      Title: Molecular function and potential evolution of the biofilm-modulating blue light-signalling pathway of Escherichia coli.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables FAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables blue light photoreceptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cyclic-guanylate-specific phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables flavin adenine dinucleotide binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables photoreceptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in blue light signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to blue light IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    blue light- and temperature-regulated antirepressor BluF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1214264..1215475 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415681.1 blue light- and temperature-regulated antirepressor BluF [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415681.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2X1JFN0
      Conserved Domains (2) summary
      smart01034
      Location:2 → 93
      BLUF; Sensors of blue-light using FAD
      smart00052
      Location:150 → 389
      EAL; Putative diguanylate phosphodiesterase
    Nucleotide Protein
    Heading Accession and Version

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