U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ychF redox-responsive ATPase YchF [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945769, updated on 3-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ychF
    Official Full Name
    redox-responsive ATPase YchF
    Primary source
    ECOCYC:EG11404
    Locus tag
    b1203
    See related
    ASAP:ABE-0004038
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1191; gtp1
    Summary
    ychF is in the pth operon; pth transcript stability depends on ychF integrity. otherPDB (H. influenzae): [More information is available at EcoGene: EG11404]. YchF is the founding member of a family of GTP-binding proteins . [More information is available at EcoCyc: EG11404].
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_000913.3 (1256721..1257812, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional dual regulator DhaR Neighboring gene putative autotransporter adhesin YcgV Neighboring gene peptidyl-tRNA hydrolase Neighboring gene stress-induced protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A universally conserved ATPase regulates the oxidative stress response in Escherichia coli. Wenk M, et al. J Biol Chem, 2012 Dec 21. PMID 23139412, Free PMC Article
    2. Deciphering the catalytic machinery in a universally conserved ribosome binding ATPase YchF. Tomar SK, et al. Biochem Biophys Res Commun, 2011 May 13. PMID 21527254
    3. Conserved P-loop GTPases of unknown function in bacteria: an emerging and vital ensemble in bacterial physiology. Brown ED. Biochem Cell Biol, 2005 Dec. PMID 16333325
    4. Transcriptional analysis of the gene encoding peptidyl-tRNA hydrolase in Escherichia coli. Cruz-Vera LR, et al. Microbiology (Reading), 2002 Nov. PMID 12427937
    5. Peptidyl-tRNA hydrolase is involved in lambda inhibition of host protein synthesis. García-Villegas MR, et al. EMBO J, 1991 Nov. PMID 1833189, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Our data provide novel insights into the regulation of the so far ill-defined YchF/Ola1 family of proteins and stipulate their role as negative regulators of the oxidative stress response
      Title: Redox Activation of the Universally Conserved ATPase YchF by Thioredoxin 1.
    2. We have thereby identified the highly conserved His-114 as critical for the ATPase activity of YchF from Escherichia coli.
      Title: Histidine 114 Is Critical for ATP Hydrolysis by the Universally Conserved ATPase YchF.
    3. Escherichia coli YchF binds the 50S and 70S ribosomal particles in a nucleotide independent manner and it hydrolyzes ATP utilizing a potassium dependent mechanism.
      Title: Deciphering the catalytic machinery in a universally conserved ribosome binding ATPase YchF.
    4. N-terminus verified by Edman degradation on mature peptide
      Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme inhibitor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ribonucleoside triphosphate phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosomal large subunit binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ribosomal large subunit binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosome binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within response to oxidative stress IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    redox-responsive ATPase YchF

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1256721..1257812 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415721.1 redox-responsive ATPase YchF [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415721.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2X1NHD9, A0A376MWI2, A0A5B9AMW6
      Conserved Domains (1) summary
      PRK09601
      Location:1 → 363
      PRK09601; redox-regulated ATPase YchF
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.