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    otsB trehalose-6-phosphate phosphatase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946406, updated on 3-Dec-2024

    Summary

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    Official Symbol
    otsB
    Official Full Name
    trehalose-6-phosphate phosphatase
    Primary source
    ECOCYC:EG11752
    Locus tag
    b1897
    See related
    ASAP:ABE-0006320
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1896; otsP
    Summary
    HAD superfamily. [More information is available at EcoGene: EG11752]. otsB encodes the biosynthetic trehalose-6-phosphate phosphatase, which belongs to the superfamily of haloacid dehalogenase (HAD)-like hydrolases. [More information is available at EcoCyc: EG11752].
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    Genomic context

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    Sequence:
    NC_000913.3 (1981587..1982387, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene IS1 family protein InsB Neighboring gene IS1 family protein InsA Neighboring gene universal stress protein C Neighboring gene trehalose-6-phosphate synthase Neighboring gene arabinose ABC transporter membrane subunit Neighboring gene arabinose ABC transporter ATP binding subunit

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The solubility of recombinant proteins expressed in Escherichia coli is increased by otsA and otsB co-transformation. Schultz T, et al. Biochem Biophys Res Commun, 2007 Mar 30. PMID 17292861
    2. Biochemical and genetic characterization of osmoregulatory trehalose synthesis in Escherichia coli. Giaever HM, et al. J Bacteriol, 1988 Jun. PMID 3131312, Free PMC Article
    3. Osmolyte-induced transcription: -35 region elements and recognition by sigma38 (rpoS). Rosenthal AZ, et al. Mol Microbiol, 2006 Feb. PMID 16420371
    4. Improved method for the preparative synthesis of labeled trehalose of high specific activity by Escherichia coli. Horlacher R, et al. Appl Environ Microbiol, 1996 Oct. PMID 8837441, Free PMC Article
    5. Trehalose synthesis is induced upon exposure of Escherichia coli to cold and is essential for viability at low temperatures. Kandror O, et al. Proc Natl Acad Sci U S A, 2002 Jul 23. PMID 12105274, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on complete protein
      Title: Analysis of the otsBA operon for osmoregulatory trehalose synthesis in Escherichia coli and homology of the OtsA and OtsB proteins to the yeast trehalose-6-phosphate synthase/phosphatase complex.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables trehalose-phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables trehalose-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within response to osmotic stress IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in trehalose biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within trehalose biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within trehalose metabolism in response to cold stress IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within trehalose metabolism in response to cold stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    trehalose-6-phosphate phosphatase
    NP_416411.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1981587..1982387 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416411.1 trehalose-6-phosphate phosphatase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416411.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      Q6PQ83
      Conserved Domains (1) summary
      PRK10187
      Location:1 → 266
      PRK10187; trehalose-6-phosphate phosphatase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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