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    pgsA CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945791, updated on 3-Dec-2024

    Summary

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    Official Symbol
    pgsA
    Official Full Name
    CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
    Primary source
    ECOCYC:EG10706
    Locus tag
    b1912
    See related
    ASAP:ABE-0006367
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1911
    Summary
    Overexpression causes filamentous biofilm formation. [More information is available at EcoGene: EG10706].
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    Genomic context

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    Sequence:
    NC_000913.3 (1992269..1992817, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene tRNA-Cys Neighboring gene tRNA-Gly Neighboring gene UvrABC excision nuclease subunit C Neighboring gene DNA-binding transcriptional activator UvrY Neighboring gene protein YecU Neighboring gene DUF2594 domain-containing protein YecF

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Activation of the Cpx phosphorelay signal transduction system in acidic phospholipid-deficient pgsA mutant cells of Escherichia coli. Itou A, et al. Biochem Biophys Res Commun, 2012 May 4. PMID 22503979
    2. Phosphatidic acid and N-acylphosphatidylethanolamine form membrane domains in Escherichia coli mutant lacking cardiolipin and phosphatidylglycerol. Mileykovskaya E, et al. J Biol Chem, 2009 Jan 30. PMID 19049984, Free PMC Article
    3. Membrane-associated phosphatidylglycerophosphate synthetase from Escherichia coli: purification by substrate affinity chromatography on cytidine 5'-diphospho-1,2-diacyl-sn-glycerol sepharose. Hirabayashi T, et al. Biochemistry, 1976 Nov 30. PMID 793612
    4. Phosphatidylglycerophosphate synthase from Escherichia coli. Dowhan W. Methods Enzymol, 1992. PMID 1323047
    5. Alteration of the phospholipid composition of Escherichia coli through genetic manipulation. Heacock PN, et al. J Biol Chem, 1989 Sep 5. PMID 2549045

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cpx system is activated also in a pgsA mutant.
      Title: Activation of the Cpx phosphorelay signal transduction system in acidic phospholipid-deficient pgsA mutant cells of Escherichia coli.
    2. In the Escherichia coli pgsA null mutant, which lacks the major acidic phospholipids, the Rcs phosphorelay signal transduction system is activated, causing thermosensitive growth.
      Title: RcsA-dependent and -independent growth defects caused by the activated Rcs phosphorelay system in the Escherichia coli pgsA null mutant.
    3. The development of a novel Escherichia coli cell surface display system by employing PgsA as an anchoring motif is reported.
      Title: Display of active enzymes on the cell surface of Escherichia coli using PgsA anchor protein and their application to bioconversion.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphotransferase activity, for other substituted phosphate groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glycerophospholipid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylglycerol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
    NP_416422.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1992269..1992817 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416422.1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416422.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5B9AJC9
      Conserved Domains (1) summary
      PRK10832
      Location:1 → 182
      PRK10832; CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
    Nucleotide Protein
    Heading Accession and Version

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