U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    fliM flagellar motor switch protein FliM [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946442, updated on 3-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    fliM
    Official Full Name
    flagellar motor switch protein FliM
    Primary source
    ECOCYC:EG10323
    Locus tag
    b1945
    See related
    ASAP:ABE-0006469
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    cheC2; ECK1943; fla; flaA; flaAII; flaQ; flaQII
    Summary
    FliGMN switch complex on the rotor of the bacterial flagellum. [More information is available at EcoGene: EG10323]. FliM is one of three components of the flagellar motor's "switch complex. [More information is available at EcoCyc: EG10323].
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_000913.3 (2020087..2021091)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene flagellar biosynthesis protein FliJ Neighboring gene flagellar hook-length control protein Neighboring gene flagellar protein FliL Neighboring gene flagellar motor switch protein FliN Neighboring gene flagellar biosynthesis protein FliO Neighboring gene flagellar biosynthesis protein FliP

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Identification of a bacterial sensing protein and effects of its elevated expression. Clegg DO, et al. J Bacteriol, 1985 Apr. PMID 2984180, Free PMC Article
    2. Subunit organization and reversal-associated movements in the flagellar switch of Escherichia coli. Sarkar MK, et al. J Biol Chem, 2010 Jan 1. PMID 19858188, Free PMC Article
    3. Structure of the constitutively active double mutant CheYD13K Y106W alone and in complex with a FliM peptide. Dyer CM, et al. J Mol Biol, 2004 Sep 24. PMID 15351654
    4. Binding of the Escherichia coli response regulator CheY to its target measured in vivo by fluorescence resonance energy transfer. Sourjik V, et al. Proc Natl Acad Sci U S A, 2002 Oct 1. PMID 12232047, Free PMC Article
    5. How 34 pegs fit into 26 + 8 holes in the flagellar motor. Manson MD. J Bacteriol, 2007 Jan. PMID 17085552, Free PMC Article

    See all (73) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mechanosensitive recruitment of stator units promotes binding of the response regulator CheY-P to the flagellar motor.
      Title: Mechanosensitive recruitment of stator units promotes binding of the response regulator CheY-P to the flagellar motor.
    2. The results indicate that FliG has a significant tendency to form multimers independently of other flagellar components. The multimerization of FliG is promoted by FliF and also by FliM.
      Title: Biogenesis of the Flagellar Switch Complex in Escherichia coli: Formation of Sub-Complexes Independently of the Basal-Body MS-Ring.
    3. The curve for the pre-adapted flagellar motor with a specific number of FliM units is about a factor of 2 steeper than the measurement in a previous study.
      Title: Ultrasensitivity of an adaptive bacterial motor.
    4. turnover of FliM molecules depends on the presence of active CheY, suggesting a potential role in the process of motor switching
      Title: Signal-dependent turnover of the bacterial flagellar switch protein FliM.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables cytoskeletal motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in archaeal or bacterial-type flagellum-dependent cell motility IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in bacterial-type flagellum-dependent cell motility IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in bacterial-type flagellum-dependent swarming motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in bacterial-type flagellum-dependent swimming motility NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chemotaxis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in bacterial-type flagellum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in bacterial-type flagellum NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in bacterial-type flagellum basal body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in bacterial-type flagellum basal body, C ring NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in bacterial-type flagellum rotor complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    flagellar motor switch protein FliM

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2020087..2021091
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416455.1 flagellar motor switch protein FliM [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416455.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2W6QAT1, A0A5B9AIZ2
      Conserved Domains (1) summary
      PRK06666
      Location:1 → 334
      fliM; flagellar motor switch protein FliM; Validated
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.