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    glf UDP-galactopyranose mutase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945235, updated on 3-Dec-2024

    Summary

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    Official Symbol
    glf
    Official Full Name
    UDP-galactopyranose mutase
    Primary source
    ECOCYC:EG11981
    Locus tag
    b2036
    See related
    ASAP:ABE-0006755
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2030; yefE
    Summary
    UDP-D-galactopyranose mutase catalyzes the reversible interconversion of UDP-galactopyranose and UDP-galactofuranose . [More information is available at EcoCyc: EG11981].
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    Genomic context

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    Sequence:
    NC_000913.3 (2107226..2108329, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative lipopolysaccharide biosynthesis O-acetyl transferase WbbJ Neighboring gene beta-1,6-galactofuranosyltransferase WbbI Neighboring gene putative O-antigen polymerase Neighboring gene polyisoprenol-linked O16-antigen repeat unit flippase Neighboring gene dTDP-4-dehydrorhamnose 3,5-epimerase Neighboring gene glucose-1-phosphate thymidylyltransferase 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Convergent and stereoselective synthesis of iminosugar-containing Galf and UDP-Galf mimicks: evaluation as inhibitors of UDP-Gal mutase. Liautard V, et al. J Org Chem, 2008 Apr 18. PMID 18358048
    2. Stereoselective synthesis of beta-1-C-substituted 1,4-dideoxy-1,4-imino-D-galactitols and evaluation as UDP-galactopyranose mutase inhibitors. Desvergnes S, et al. Bioorg Med Chem, 2007 Oct 1. PMID 17662609
    3. Reconstitution of UDP-galactopyranose mutase with 1-deaza-FAD and 5-deaza-FAD: analysis and mechanistic implications. Huang Z, et al. Bioorg Chem, 2003 Dec. PMID 14613770
    4. UDP-galactopyranose mutase has a novel structure and mechanism. Sanders DA, et al. Nat Struct Biol, 2001 Oct. PMID 11573090
    5. Mechanistic investigation of UDP-galactopyranose mutase from Escherichia coli using 2- and 3-fluorinated UDP-galactofuranose as probes. Zhang Q, et al. J Am Chem Soc, 2001 Jul 18. PMID 11448178

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on complete protein
      Title: Galactofuranose biosynthesis in Escherichia coli K-12: identification and cloning of UDP-galactopyranose mutase.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables UDP-galactopyranose mutase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables UDP-galactopyranose mutase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables UDP-galactopyranose mutase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables flavin adenine dinucleotide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables flavin adenine dinucleotide binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in lipopolysaccharide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    UDP-galactopyranose mutase
    NP_416540.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2107226..2108329 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416540.1 UDP-galactopyranose mutase [Escherichia coli str. K-12 substr. MG1655]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P37747
      Conserved Domains (1) summary
      COG0562
      Location:1 → 367
      Glf; UDP-galactopyranose mutase [Cell wall/membrane/envelope biogenesis]
    Nucleotide Protein
    Heading Accession and Version

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