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    napD NapA signal peptide-binding chaperone NapD [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945187, updated on 3-Dec-2024

    Summary

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    Official Symbol
    napD
    Official Full Name
    NapA signal peptide-binding chaperone NapD
    Primary source
    ECOCYC:EG12143
    Locus tag
    b2207
    See related
    ASAP:ABE-0007291
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2199; yojF
    Summary
    Nap has a strong anti-transport actvity in vitro, but is essential for NapA activity and transport in vivo. [More information is available at EcoGene: EG12143]. NapD is a dedicated chaperone for NapA, the molybdoprotein subunit of the periplasmic nitrate reductase. [More information is available at EcoCyc: EG12143].
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    Genomic context

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    Sequence:
    NC_000913.3 (2302750..2303013, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene periplasmic nitrate reductase cytochrome c550 protein Neighboring gene ferredoxin-type protein NapH Neighboring gene ferredoxin-type protein NapG Neighboring gene periplasmic nitrate reductase subunit NapA Neighboring gene ferredoxin-type protein Neighboring gene uncharacterized protein YojO Neighboring gene serine protease inhibitor ecotin

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of a periplasmic nitrate reductase in complex with its biosynthetic chaperone. Dow JM, et al. FEBS J, 2014 Jan. PMID 24314029, Free PMC Article
    2. Overlapping transport and chaperone-binding functions within a bacterial twin-arginine signal peptide. Grahl S, et al. Mol Microbiol, 2012 Mar. PMID 22329966, Free PMC Article
    3. Structural diversity in twin-arginine signal peptide-binding proteins. Maillard J, et al. Proc Natl Acad Sci U S A, 2007 Oct 2. PMID 17901208, Free PMC Article
    4. Comparing system-specific chaperone interactions with their Tat dependent redox enzyme substrates. Chan CS, et al. FEBS Lett, 2010 Nov 19. PMID 20974141, Free PMC Article
    5. Nitrate reduction to ammonia by enteric bacteria: redundancy, or a strategy for survival during oxygen starvation? Cole J. FEMS Microbiol Lett, 1996 Feb 1. PMID 8919448

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The NapA signal peptide adopts an alpha-helical conformation upon binding NapD.
      Title: Overlapping transport and chaperone-binding functions within a bacterial twin-arginine signal peptide.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signal sequence binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signal sequence binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of protein transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    NapA signal peptide-binding chaperone NapD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2302750..2303013 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416711.1 NapA signal peptide-binding chaperone NapD [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416711.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A828PCB3
      Conserved Domains (1) summary
      PRK10553
      Location:1 → 87
      PRK10553; chaperone NapD
    Nucleotide Protein
    Heading Accession and Version

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