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    yfeW penicillin binding protein 4B [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946907, updated on 3-Dec-2024

    Summary

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    Official Symbol
    yfeW
    Official Full Name
    penicillin binding protein 4B
    Primary source
    ECOCYC:G7265
    Locus tag
    b2430
    See related
    ASAP:ABE-0008012
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2425
    Summary
    A mutation in yfeW(pbp4a) does not affect growth on MurNAc (Jaeger, 2008). yfeW(pbp4a) is probably transcribed as part of the murQP-yfeW operon and from a promoter within murP (Jaeger, 2008). [More information is available at EcoGene: EG14164].
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    Genomic context

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    Sequence:
    NC_000913.3 (2548102..2549406)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene N-acetylmuramic acid 6-phosphate etherase Neighboring gene N-acetylmuramic acid-specific PTS enzyme IICB component/anhydro-N-acetylmuramic acid transporter Neighboring gene porphyrinogen peroxidase Neighboring gene DUF1131 domain-containing lipoprotein YfeY

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The DD-carboxypeptidase activity encoded by pbp4B is not essential for the cell growth of Escherichia coli. Vega D, et al. Arch Microbiol, 2006 Mar. PMID 16402224
    2. The transcriptional factors MurR and catabolite activator protein regulate N-acetylmuramic acid catabolism in Escherichia coli. Jaeger T, et al. J Bacteriol, 2008 Oct. PMID 18723630, Free PMC Article
    3. Prediction of lipoprotein signal peptides in Gram-negative bacteria. Juncker AS, et al. Protein Sci, 2003 Aug. PMID 12876315, Free PMC Article
    4. Fine-tuning the prediction of sequences cleaved by signal peptidase II: a curated set of proven and predicted lipoproteins of Escherichia coli K-12. Gonnet P, et al. Proteomics, 2004 Jun. PMID 15174130
    5. MEROPS: the peptidase database. Rawlings ND, et al. Nucleic Acids Res, 2006 Jan 1. PMID 16381862, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables carboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables penicillin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables serine-type D-Ala-D-Ala carboxypeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables serine-type D-Ala-D-Ala carboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    penicillin binding protein 4B

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2548102..2549406
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416925.2 penicillin binding protein 4B [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416925.2

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8T6PYB3
      Conserved Domains (1) summary
      PRK03642
      Location:1 → 432
      PRK03642; putative periplasmic esterase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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