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    upp uracil phosphoribosyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946979, updated on 3-Dec-2024

    Summary

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    Official Symbol
    upp
    Official Full Name
    uracil phosphoribosyltransferase
    Primary source
    ECOCYC:EG11332
    Locus tag
    b2498
    See related
    ASAP:ABE-0008224
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2494; uraP
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    Genomic context

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    Sequence:
    NC_000913.3 (2620246..2620872, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene inibitor of reinitiation of DNA replication Neighboring gene uracil:H(+) symporter UraA Neighboring gene phosphoribosylformylglycinamide cyclo-ligase Neighboring gene phosphoribosylglycinamide formyltransferase 1 Neighboring gene polyphosphate kinase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Purification and some properties of uracil phosphoribosyltransferase from Escherichia coli K12. Rasmussen UB, et al. Biochim Biophys Acta, 1986 Apr 11. PMID 3513846
    2. Different oligomeric states are involved in the allosteric behavior of uracil phosphoribosyltransferase from Escherichia coli. Jensen KF, et al. Eur J Biochem, 1996 Sep 15. PMID 8856065
    3. Expression of Escherichia coli uracil phosphoribosyltransferase gene in murine colon carcinoma cells augments the antitumoral effect of 5-fluorouracil and induces protective immunity. Kawamura K, et al. Cancer Gene Ther, 2000 Apr. PMID 10811483
    4. A long T. A tract in the upp initially transcribed region is required for regulation of upp expression by UTP-dependent reiterative transcription in Escherichia coli. Cheng Y, et al. J Bacteriol, 2001 Jan. PMID 11114920, Free PMC Article
    5. Mutants of Escherichia coli unable to metabolize cytidine: isolation and characterization. Hammer-Jespersen K, et al. Mol Gen Genet, 1973 Nov 2. PMID 4360102

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on complete protein
      Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanosine tetraphosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables uracil phosphoribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables uracil phosphoribosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables uracil phosphoribosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in UMP salvage IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within pyrimidine nucleobase metabolic process EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in uracil salvage IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane HDA PubMed 

    General protein information

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    Preferred Names
    uracil phosphoribosyltransferase
    NP_416993.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2620246..2620872 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416993.2 uracil phosphoribosyltransferase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416993.2

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A775YYU0
      Conserved Domains (1) summary
      PRK00129
      Location:1 → 208
      upp; uracil phosphoribosyltransferase; Reviewed
    Nucleotide Protein
    Heading Accession and Version

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