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    lhgD L-2-hydroxyglutarate dehydrogenase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948069, updated on 3-Dec-2024

    Summary

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    Official Symbol
    lhgD
    Official Full Name
    L-2-hydroxyglutarate dehydrogenase
    Primary source
    ECOCYC:EG12387
    Locus tag
    b2660
    See related
    ASAP:ABE-0008756
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2654; lhgO; ygaF
    Summary
    LhgO is an L-2-hydroxyglutarate oxidase that is probably involved with recovering alpha-ketoglutarate (Kalliri, 2008). [More information is available at EcoGene: EG12387]. LhgO is a L-2-hydroxyglutarate oxidase that contains an FAD cofactor which is not covalently attached. [More information is available at EcoCyc: EG12387].
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    Genomic context

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    Sequence:
    NC_000913.3 (2789982..2791250)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene glutarate dioxygenase GlaH Neighboring gene succinate-semialdehyde dehydrogenase (NADP(+)) GabD Neighboring gene 4-aminobutyrate aminotransferase GabT

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of Escherichia coli YgaF as an L-2-hydroxyglutarate oxidase. Kalliri E, et al. J Bacteriol, 2008 Jun. PMID 18390652, Free PMC Article
    2. Role of activator site position and a distal UP-element half-site for sigma factor selectivity at a CRP/H-NS-activated sigma(s)-dependent promoter in Escherichia coli. Germer J, et al. Mol Microbiol, 2001 Aug. PMID 11532138
    3. Multiple stress signal integration in the regulation of the complex sigma S-dependent csiD-ygaF-gabDTP operon in Escherichia coli. Metzner M, et al. Mol Microbiol, 2004 Feb. PMID 14731280
    4. What makes an Escherichia coli promoter sigma(S) dependent? Role of the -13/-14 nucleotide promoter positions and region 2.5 of sigma(S). Becker G, et al. Mol Microbiol, 2001 Mar. PMID 11251833
    5. DNA microarray-based identification of genes controlled by autoinducer 2-stimulated quorum sensing in Escherichia coli. DeLisa MP, et al. J Bacteriol, 2001 Sep. PMID 11514505, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables (S)-2-hydroxyglutarate dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 2-hydroxyglutarate dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 2-hydroxyglutarate dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 2-hydroxyglutarate dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables flavin adenine dinucleotide binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on CH-OH group of donors IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in L-lysine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lysine catabolic process EXP
    Inferred from Experiment
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    L-2-hydroxyglutarate dehydrogenase
    NP_417146.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2789982..2791250
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417146.2 L-2-hydroxyglutarate dehydrogenase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417146.2

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6N8NQC6
      Conserved Domains (1) summary
      PRK11728
      Location:1 → 393
      PRK11728; L-2-hydroxyglutarate oxidase
    Nucleotide Protein
    Heading Accession and Version

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