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    casA type I-E CRISPR system Cascade subunit CasA [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947222, updated on 3-Dec-2024

    Summary

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    Official Symbol
    casA
    Official Full Name
    type I-E CRISPR system Cascade subunit CasA
    Primary source
    ECOCYC:G7430
    Locus tag
    b2760
    See related
    ASAP:ABE-0009050
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    cse1; ECK2755; ygcL
    Summary
    The Cascade antiviral complex is comprised of CasABCDE and short CRISP RNAs (crRNAs) and requires the predicted helicase YgcB(Cas3) for activity (Brouns , 2008). [More information is available at EcoGene: EG13119]. Transcription is regulated by BaeR, which plays a role in novobiocin and deoxycholate resistance . [More information is available at EcoCyc: G7430].
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    Genomic context

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    Sequence:
    NC_000913.3 (2882630..2884138, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene pre-CRISPR RNA endonuclease Neighboring gene type I-E CRISPR system Cascade subunit CasD Neighboring gene type I-E CRISPR system Cascade subunit CasC Neighboring gene type I-E CRISPR system Cascade subunit CasB Neighboring gene CRISPR-associated endonuclease/helicase Cas3 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CasA mediates Cas3-catalyzed target degradation during CRISPR RNA-guided interference. Hochstrasser ML, et al. Proc Natl Acad Sci U S A, 2014 May 6. PMID 24748111, Free PMC Article
    2. Structural biology. Crystal structure of the CRISPR RNA-guided surveillance complex from Escherichia coli. Jackson RN, et al. Science, 2014 Sep 19. PMID 25103409, Free PMC Article
    3. Molecular biology. Secret weapon. Young RF 3rd. Science, 2008 Aug 15. PMID 18703730, Free PMC Article
    4. The baeSR two-component regulatory system activates transcription of the yegMNOB (mdtABCD) transporter gene cluster in Escherichia coli and increases its resistance to novobiocin and deoxycholate. Baranova N, et al. J Bacteriol, 2002 Aug. PMID 12107134, Free PMC Article
    5. Structural biology. Crystal structure of a CRISPR RNA-guided surveillance complex bound to a ssDNA target. Mulepati S, et al. Science, 2014 Sep 19. PMID 25123481, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in CRISPR-cas system IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in defense response to virus IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within defense response to virus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    type I-E CRISPR system Cascade subunit CasA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2882630..2884138 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417240.1 type I-E CRISPR system Cascade subunit CasA [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417240.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8T6BET3
      Conserved Domains (1) summary
      PRK09693
      Location:1 → 489
      PRK09693; Cascade antiviral complex protein; Validated
    Nucleotide Protein
    Heading Accession and Version

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