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    fucA L-fuculose-phosphate aldolase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947282, updated on 3-Dec-2024

    Summary

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    Official Symbol
    fucA
    Official Full Name
    L-fuculose-phosphate aldolase
    Primary source
    ECOCYC:EG10348
    Locus tag
    b2800
    See related
    ASAP:ABE-0009179
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2795; fucC; prd
    Summary
    FucA can function as both an L-fuculose-phosphate aldolase and a D-ribulose-phosphate aldolase, the third enzyme of the L-fucose and D-arabinose degradation pathways, respectively. [More information is available at EcoCyc: EG10348].
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    Genomic context

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    Sequence:
    NC_000913.3 (2933041..2933688, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene flap endonuclease Neighboring gene L-1,2-propanediol oxidoreductase Neighboring gene L-fucose:H(+) symporter Neighboring gene L-fucose isomerase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Refined high-resolution structure of the metal-ion dependent L-fuculose-1-phosphate aldolase (class II) from Escherichia coli. Dreyer MK, et al. Acta Crystallogr D Biol Crystallogr, 1996 Nov 1. PMID 15299567
    2. The metabolism of L-fucose. II. The enzymatic cleavage of L-fuculose 1-phosphate. GHALAMBOR MA, et al. J Biol Chem, 1962 Aug. PMID 13898172
    3. Structures of l-fuculose-1-phosphate aldolase mutants outlining motions during catalysis. Joerger AC, et al. J Mol Biol, 2000 Nov 3. PMID 11054289
    4. Catalytic action of fuculose 1-phosphate aldolase (class II) as derived from structure-directed mutagenesis. Joerger AC, et al. Biochemistry, 2000 May 23. PMID 10821675
    5. A route for fructose utilization by Escherichia coli involving the fucose regulon. Kornberg H, et al. Proc Natl Acad Sci U S A, 2006 Dec 19. PMID 17159144, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A deletion of the fucA gene leads to induction of the proton-linked fucose transporter, FucP.
      Title: A route for fructose utilization by Escherichia coli involving the fucose regulon.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables L-fuculose-phosphate aldolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables L-fuculose-phosphate aldolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aldehyde-lyase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aldehyde-lyase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables carbon-carbon lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within D-arabinose catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in L-fucose catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within L-fucose catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in arabinose catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fucose catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fucose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monosaccharide metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pentose catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    L-fuculose-phosphate aldolase
    NP_417280.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2933041..2933688 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417280.1 L-fuculose-phosphate aldolase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417280.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6M9WZ48
      Conserved Domains (1) summary
      PRK08087
      Location:1 → 215
      PRK08087; L-fuculose-phosphate aldolase
    Nucleotide Protein
    Heading Accession and Version

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