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    yqhD NADPH-dependent aldehyde reductase YqhD [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947493, updated on 3-Dec-2024

    Summary

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    Official Symbol
    yqhD
    Official Full Name
    NADPH-dependent aldehyde reductase YqhD
    Primary source
    ECOCYC:G7564
    Locus tag
    b3011
    See related
    ASAP:ABE-0009888
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3003
    Summary
    AFMB Structural Genomics target Number 57 (http://afmb.cnrs-mrs.fr/article171.html). [More information is available at EcoGene: EG13014]. YqhD is an NADP-dependent aldehyde dehydrogenase which may be part of a glutathione-independent response to lipid peroxidation . report that various alcohols, aldehydes, amino acids, sugars and -hydroxy acids were tested as substrates for YqhD. [More information is available at EcoCyc: G7564].
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    Genomic context

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    Sequence:
    NC_000913.3 (3155355..3156518)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DedA family protein YghB Neighboring gene DNA-binding transcriptional activator YqhC Neighboring gene methylglyoxal reductase DkgA Neighboring gene DUF3828 domain-containing protein YqhG

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of E.coli alcohol dehydrogenase YqhD: evidence of a covalently modified NADP coenzyme. Sulzenbacher G, et al. J Mol Biol, 2004 Sep 10. PMID 15327949
    2. Microbial conversion of glycerol to 1,3-propanediol by an engineered strain of Escherichia coli. Tang X, et al. Appl Environ Microbiol, 2009 Mar. PMID 19139229, Free PMC Article
    3. [Construction of novel recombinant Escherichia coli capable of producing 1,3-propanediol]. Zhang XM, et al. Sheng Wu Gong Cheng Xue Bao, 2005 Sep. PMID 16285515
    4. Escherichia coli YqhD exhibits aldehyde reductase activity and protects from the harmful effect of lipid peroxidation-derived aldehydes. Pérez JM, et al. J Biol Chem, 2008 Mar 21. PMID 18211903
    5. Production of 1,3-propanediol from glycerol by recombinant E. coli using incompatible plasmids system. Wang F, et al. Mol Biotechnol, 2007 Oct. PMID 17914171

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The authors propose that YqhC is a transcriptional activator of YqhD, which acts as an aldehyde reductase with specificity for certain aldehydes, including glyoxal.
      Title: Transcriptional activation of the aldehyde reductase YqhD by YqhC and its implication in glyoxal metabolism of Escherichia coli K-12.
    2. A model is proposed for the inhibition of growth in which the reduction of furfural by YqhD enzyme depletes NADPH sufficiently to limit the assimilation of sulfur into amino acids (cysteine and methionine) by CysIJ (sulfite reductase).
      Title: Furfural inhibits growth by limiting sulfur assimilation in ethanologenic Escherichia coli strain LY180.
    3. Purified enzymes encoded by yqhD and dkgA were shown to have NADPH-dependent furfural reductase activity.
      Title: Silencing of NADPH-dependent oxidoreductase genes (yqhD and dkgA) in furfural-resistant ethanologenic Escherichia coli.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables alcohol dehydrogenase (NADP+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alcohol dehydrogenase (NADP+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables alcohol dehydrogenase (NADP+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alcohol dehydrogenase [NAD(P)+] activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alcohol dehydrogenase [NAD(P)+] activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables butanol dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methylglyoxal reductase (NADPH) (acetol producing) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methylglyoxal reductase (NADPH) (acetol producing) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within response to reactive oxygen species IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NADPH-dependent aldehyde reductase YqhD
    NP_417484.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3155355..3156518
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417484.1 NADPH-dependent aldehyde reductase YqhD [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417484.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376M2D1, A0A8S7CRS2
      Conserved Domains (1) summary
      PRK15138
      Location:1 → 387
      PRK15138; alcohol dehydrogenase
    Nucleotide Protein
    Heading Accession and Version

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