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    yhaV ribosome-dependent mRNA interferase toxin YhaV [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947638, updated on 3-Dec-2024

    Summary

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    Official Symbol
    yhaV
    Official Full Name
    ribosome-dependent mRNA interferase toxin YhaV
    Primary source
    ECOCYC:G7629
    Locus tag
    b3130
    See related
    ASAP:ABE-0010289
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3118
    Summary
    YhaV is the toxin component of the PrlF-YhaV antitoxin-toxin complex. [More information is available at EcoCyc: G7629].
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    Genomic context

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    Sequence:
    NC_000913.3 (3277337..3277801)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene galactarate/D-glucarate transporter GarP Neighboring gene GarD Neighboring gene antitoxin PrlF Neighboring gene DNA-binding transcriptional repressor AgaR Neighboring gene putative tagatose-1,6-bisphosphate aldolase 1 chaperone

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Global Analysis of the Specificities and Targets of Endoribonucleases from Escherichia coli Toxin-Antitoxin Systems. Culviner PH, et al. mBio, 2021 Oct 26. PMID 34544284, Free PMC Article
    2. Functional Characterization of the C-Terminus of YhaV in the Escherichia coli PrlF-YhaV Toxin-Antitoxin System. Choi W, et al. J Microbiol Biotechnol, 2018 Jun 28. PMID 29642286
    3. Translation-dependent mRNA cleavage by YhaV in Escherichia coli. Choi W, et al. FEBS Lett, 2017 Jul. PMID 28573789
    4. mRNA interferases, sequence-specific endoribonucleases from the toxin-antitoxin systems. Yamaguchi Y, et al. Prog Mol Biol Transl Sci, 2009. PMID 19215780
    5. Increased expression of the bifunctional protein PrlF suppresses overproduction lethality associated with exported beta-galactosidase hybrid proteins in Escherichia coli. Kiino DR, et al. J Bacteriol, 1990 Jan. PMID 2152898, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results suggest that the YhaV C-terminal region is essential for mRNA interferase activity, and the W143 or H154 residues may play an analogous role to Y87 of RelE.
      Title: Functional Characterization of the C-Terminus of YhaV in the Escherichia coli PrlF-YhaV Toxin-Antitoxin System.
    2. Data show that prlF and yhaV encode a novel toxin-antitoxin system in Escherichia coli.
      Title: prlF and yhaV encode a new toxin-antitoxin system in Escherichia coli.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables RNA endonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA nuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA nuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ribosomal large subunit binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of cell growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of growth NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in single-species biofilm formation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of toxin-antitoxin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of toxin-antitoxin complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ribosome-dependent mRNA interferase toxin YhaV
    NP_417599.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3277337..3277801
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417599.1 ribosome-dependent mRNA interferase toxin YhaV [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417599.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A775UC43
      Conserved Domains (1) summary
      pfam11663
      Location:12 → 143
      Toxin_YhaV; Toxin with endonuclease activity, of toxin-antitoxin system
    Nucleotide Protein
    Heading Accession and Version

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