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    nlpI lipoprotein NlpI [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947673, updated on 3-Dec-2024

    Summary

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    Official Symbol
    nlpI
    Official Full Name
    lipoprotein NlpI
    Primary source
    ECOCYC:EG12371
    Locus tag
    b3163
    See related
    ASAP:ABE-0010395
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3151; yhbM
    Summary
    First 18 aa are a type II signal peptide. [More information is available at EcoGene: EG12371]. NlpI is a lipoprotein that appears to be involved in cell division . [More information is available at EcoCyc: EG12371].
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    Genomic context

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    Sequence:
    NC_000913.3 (3308040..3308924, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene tryptophan:H(+) symporter Mtr Neighboring gene ATP-dependent RNA helicase DeaD Neighboring gene uncharacterized protein YrbN Neighboring gene polynucleotide phosphorylase Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of a new lipoprotein, NlpI, in Escherichia coli K-12. Ohara M, et al. J Bacteriol, 1999 Jul. PMID 10400590, Free PMC Article
    2. Involvement of lipoprotein NlpI in the virulence of adherent invasive Escherichia coli strain LF82 isolated from a patient with Crohn's disease. Barnich N, et al. Infect Immun, 2004 May. PMID 15102755, Free PMC Article
    3. Heat shock proteins IbpA and IbpB are required for NlpI-participated cell division in Escherichia coli. Tao J, et al. Front Microbiol, 2015. PMID 25699035, Free PMC Article
    4. The crystal structure of NlpI. A prokaryotic tetratricopeptide repeat protein with a globular fold. Wilson CG, et al. FEBS J, 2005 Jan. PMID 15634341
    5. Release of outer membrane vesicles by Gram-negative bacteria is a novel envelope stress response. McBroom AJ, et al. Mol Microbiol, 2007 Jan. PMID 17163978, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Outer membrane lipoprotein NlpI scaffolds peptidoglycan hydrolases within multi-enzyme complexes in Escherichia coli.
      Title: Outer membrane lipoprotein NlpI scaffolds peptidoglycan hydrolases within multi-enzyme complexes in Escherichia coli.
    2. A proteolytic system comprising the periplasmic PDZ-protease Prc and the lipoprotein adaptor NlpI contributes to Peptidoglycan (PG) enlargement.
      Title: Structural basis of adaptor-mediated protein degradation by the tail-specific PDZ-protease Prc.
    3. NlpI negatively affects eDNA release since the overexpression of nlpI decreases eDNA 16 fold while deleting nlpI increases eDNA threefold.
      Title: Global regulator H-NS and lipoprotein NlpI influence production of extracellular DNA in Escherichia coli.
    4. presents the high-resolution structure of NlpI, the first structure of a complete TPR-containing protein
      Title: The crystal structure of NlpI. A prokaryotic tetratricopeptide repeat protein with a globular fold.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-macromolecule adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-macromolecule adaptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within peptidoglycan metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    lipoprotein NlpI

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3308040..3308924 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417632.1 lipoprotein NlpI [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417632.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8T5Z9X1
      Conserved Domains (2) summary
      PRK11189
      Location:1 → 294
      PRK11189; lipoprotein NlpI; Provisional
      sd00006
      Location:62 → 90
      TPR; TPR repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version

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