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    ppiA peptidyl-prolyl cis-trans isomerase A [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947870, updated on 3-Dec-2024

    Summary

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    Official Symbol
    ppiA
    Official Full Name
    peptidyl-prolyl cis-trans isomerase A
    Primary source
    ECOCYC:EG10757
    Locus tag
    b3363
    See related
    ASAP:ABE-0010992
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3351; rot; rotA
    Summary
    An fkpA, surA, ppiB, ppiD quadruple mutant is viable. [More information is available at EcoGene: EG10757]. PpiA is a peptidyl-prolyl cis-trans-isomerase (PPIase), catalyzing the conformational isomerization of prolyl residues in peptides. [More information is available at EcoCyc: EG10757].
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    Genomic context

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    Sequence:
    NC_000913.3 (3491725..3492297, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene aminodeoxychorismate synthase subunit 2 Neighboring gene putative adenosine monophosphate--protein transferase Fic Neighboring gene DUF2559 domain-containing protein YhfG Neighboring gene putative transporter TsgA Neighboring gene nitrite reductase (NADH) large subunit Neighboring gene nitrite reductase (NADH) small subunit

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Peptidyl-prolyl cis-trans-isomerase from Escherichia coli: a periplasmic homolog of cyclophilin that is not inhibited by cyclosporin A. Liu J, et al. Proc Natl Acad Sci U S A, 1990 Jun. PMID 2190212, Free PMC Article
    2. Escherichia coli cyclophilin B binds a highly distorted form of trans-prolyl peptide isomer. Konno M, et al. Eur J Biochem, 2004 Sep. PMID 15355356
    3. Three-dimensional solution structure of Escherichia coli periplasmic cyclophilin. Clubb RT, et al. Biochemistry, 1994 Mar 15. PMID 8130188
    4. The mutant Escherichia coli F112W cyclophilin binds cyclosporin A in nearly identical conformation as human cyclophilin. Fejzo J, et al. Biochemistry, 1994 May 17. PMID 8180197
    5. Characterization of an Escherichia coli rotA mutant, affected in periplasmic peptidyl-prolyl cis/trans isomerase. Kleerebezem M, et al. Mol Microbiol, 1995 Oct. PMID 8709850

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on mature peptide
      Title: Peptidyl-prolyl cis-trans-isomerase from Escherichia coli: a periplasmic homolog of cyclophilin that is not inhibited by cyclosporin A.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables RNA polymerase II CTD heptapeptide repeat P3 isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat P6 isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptidyl-prolyl cis-trans isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in outer membrane-bounded periplasmic space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in periplasmic space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in periplasmic space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    peptidyl-prolyl cis-trans isomerase A
    NP_417822.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3491725..3492297 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417822.1 peptidyl-prolyl cis-trans isomerase A [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417822.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376JR54, A0AAN3H6V2
      Conserved Domains (1) summary
      PRK10903
      Location:1 → 190
      PRK10903; peptidylprolyl isomerase A
    Nucleotide Protein
    Heading Accession and Version

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