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    pdeH c-di-GMP phosphodiesterase PdeH [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948042, updated on 3-Dec-2024

    Summary

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    Official Symbol
    pdeH
    Official Full Name
    c-di-GMP phosphodiesterase PdeH
    Primary source
    ECOCYC:EG12252
    Locus tag
    b3525
    See related
    ASAP:ABE-0011515
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3510; yhjH
    Summary
    Overexpressed Salmonella typhimurium YhjH (STM3611) enhances motitility, counteracts cellulose biosynthesis and the rdar phenotype, and mediates cyclic-di-GMP degradation. [More information is available at EcoGene: EG12252]. YhjH is a c-di-GMP phosphodiesterase involved in regulation of the switch from flagellar motility to sessile behavior and curli expression at the end of exponential growth . [More information is available at EcoCyc: EG12252].
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    Genomic context

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    Sequence:
    NC_000913.3 (3678420..3679187, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative transporter YhjE Neighboring gene AsmA family protein YhjG Neighboring gene 2-dehydro-3-deoxygluconokinase Neighboring gene peptidase M16 family protein YhjJ

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of Salmonella enterica serovar Typhimurium genes associated with growth suppression in stationary-phase nutrient broth cultures and in the chicken intestine. Rychlik I, et al. Arch Microbiol, 2002 Dec. PMID 12420160
    2. Two novel flagellar components and H-NS are involved in the motor function of Escherichia coli. Ko M, et al. J Mol Biol, 2000 Oct 27. PMID 11031114
    3. The flagellar sigma factor FliA regulates adhesion and invasion of Crohn disease-associated Escherichia coli via a cyclic dimeric GMP-dependent pathway. Claret L, et al. J Biol Chem, 2007 Nov 16. PMID 17827157
    4. A comprehensive genetic characterization of bacterial motility. Girgis HS, et al. PLoS Genet, 2007 Sep. PMID 17941710, Free PMC Article
    5. C-di-GMP: the dawning of a novel bacterial signalling system. Römling U, et al. Mol Microbiol, 2005 Aug. PMID 16045609

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables cyclic-guanylate-specific phosphodiesterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cyclic-guanylate-specific phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of bacterial-type flagellum-dependent cell motility IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    c-di-GMP phosphodiesterase PdeH
    NP_417982.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3678420..3679187 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417982.2 c-di-GMP phosphodiesterase PdeH [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417982.2

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376M2F6
      Conserved Domains (1) summary
      PRK11596
      Location:1 → 255
      PRK11596; cyclic-di-GMP phosphodiesterase; Provisional
    Nucleotide Protein
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