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    mobB molybdopterin-guanine dinucleotide biosynthesis adaptor protein [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948343, updated on 17-Dec-2024

    Summary

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    Official Symbol
    mobB
    Official Full Name
    molybdopterin-guanine dinucleotide biosynthesis adaptor protein
    Primary source
    ECOCYC:EG11828
    Locus tag
    b3856
    See related
    ASAP:ABE-0012591
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3848; yihC
    Summary
    MobB has a weak intrinsic GTP-binding and GTPase activity that may be enhanced by interaction with MobA. [More information is available at EcoGene: EG11828]. Molybdenum and tungsten cofactors of all enzymes, with the exception of nitrogenase, that require one or the other of the other for activity are present in an oxidized state as molybdate or tungstate ions that are chelated by the cis-dithiolene moiety of a molybdenum cofactor. [More information is available at EcoCyc: EG11828].
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    Genomic context

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    Sequence:
    NC_000913.3 (4040906..4041433, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene 23S ribosomal RNA Neighboring gene 5S ribosomal RNA Neighboring gene molybdenum cofactor guanylyltransferase Neighboring gene DUF1040 domain-containing protein YihD Neighboring gene stress response kinase A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecules of Escherichia coli MobB assemble into densely packed hollow cylinders in a crystal lattice with 75% solvent content. Rangarajan SE, et al. Acta Crystallogr D Biol Crystallogr, 2003 Dec. PMID 14646116
    2. The product of the molybdenum cofactor gene mobB of Escherichia coli is a GTP-binding protein. Eaves DJ, et al. Eur J Biochem, 1997 Jun 15. PMID 9219527
    3. The mob locus of Escherichia coli K12 required for molybdenum cofactor biosynthesis is expressed at very low levels. Iobbi-Nivol C, et al. Microbiology (Reading), 1995 Jul. PMID 7551035
    4. Involvement of the narJ and mob gene products in distinct steps in the biosynthesis of the molybdoenzyme nitrate reductase in Escherichia coli. Palmer T, et al. Mol Microbiol, 1996 May. PMID 8793883
    5. In vivo interactions between gene products involved in the final stages of molybdenum cofactor biosynthesis in Escherichia coli. Magalon A, et al. J Biol Chem, 2002 Dec 13. PMID 12372836

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on mature peptide
      Title: The mob locus of Escherichia coli K12 required for molybdenum cofactor biosynthesis is expressed at very low levels.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Mo-molybdopterin cofactor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    molybdopterin-guanine dinucleotide biosynthesis adaptor protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4040906..4041433 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418293.2 molybdopterin-guanine dinucleotide biosynthesis adaptor protein [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418293.2

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0AAN3M7S7, A0AAN4SW59
      Conserved Domains (1) summary
      PRK10751
      Location:2 → 174
      PRK10751; molybdopterin-guanine dinucleotide biosynthesis protein B; Provisional
    Nucleotide Protein
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