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    glnL protein histidine kinase NtrB [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948360, updated on 3-Dec-2024

    Summary

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    Official Symbol
    glnL
    Official Full Name
    protein histidine kinase NtrB
    Primary source
    ECOCYC:EG10387
    Locus tag
    b3869
    See related
    ASAP:ABE-0012634
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3862; glnR; ntrB
    Summary
    NtrB belongs to the transmitter-protein family of the conserved two-component system of signal transduction NtrB/NtrC , and is involved in response to limitation of nitrogen . [More information is available at EcoCyc: EG10387].
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    Genomic context

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    Sequence:
    NC_000913.3 (4055290..4056339, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein YshB Neighboring gene DNA-binding transcriptional dual regulator NtrC Neighboring gene glutamine synthetase Neighboring gene 50S ribosomal subunit assembly factor BipA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of the reconstituted UTase/UR-PII-NRII-NRI bicyclic signal transduction system that controls the transcription of nitrogen-regulated (Ntr) genes in Escherichia coli. Jiang P, et al. Biochemistry, 2012 Nov 13. PMID 23088566
    2. Identification of the site of autophosphorylation of the bacterial protein kinase/phosphatase NRII. Ninfa AJ, et al. J Biol Chem, 1991 Apr 15. PMID 2016302
    3. Protein kinase and phosphoprotein phosphatase activities of nitrogen regulatory proteins NTRB and NTRC of enteric bacteria: roles of the conserved amino-terminal domain of NTRC. Keener J, et al. Proc Natl Acad Sci U S A, 1988 Jul. PMID 2839825, Free PMC Article
    4. Mechanism of regulation of the bifunctional histidine kinase NtrB in Escherichia coli. Weiss V, et al. J Mol Microbiol Biotechnol, 2002 May. PMID 11931552
    5. Purification of nitrogen regulator II, the product of the glnL (ntrB) gene of Escherichia coli. Ninfa AJ, et al. J Bacteriol, 1986 Nov. PMID 3536843, Free PMC Article

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the bicyclic system produced a graded response of NRI phosphorylation to glutamine under a range of conditions, and under most conditions the response of NRI phosphorylation state to glutamine levels depended on the concentrations of NRI, NRII, and PII
      Title: Characterization of the reconstituted UTase/UR-PII-NRII-NRI bicyclic signal transduction system that controls the transcription of nitrogen-regulated (Ntr) genes in Escherichia coli.
    2. N-terminus verified by Edman degradation on mature peptide
      Title: Identification of the site of autophosphorylation of the bacterial protein kinase/phosphatase NRII.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphorelay sensor kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphotransferase activity, carboxyl group as acceptor IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein histidine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein histidine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in nitrogen fixation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphorelay signal transduction system IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction involved in regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein histidine kinase NtrB
    NP_418305.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4055290..4056339 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418305.1 protein histidine kinase NtrB [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418305.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376MMB8
      Conserved Domains (1) summary
      PRK11073
      Location:1 → 348
      glnL; nitrogen regulation protein NR(II)
    Nucleotide Protein
    Heading Accession and Version

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