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    fhuB iron(III) hydroxamate ABC transporter membrane subunit [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946890, updated on 3-Dec-2024

    Summary

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    Official Symbol
    fhuB
    Official Full Name
    iron(III) hydroxamate ABC transporter membrane subunit
    Primary source
    ECOCYC:EG10303
    Locus tag
    b0153
    See related
    ASAP:ABE-0000526
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0152
    Summary
    fhuB mutants are albomycin resistant. [More information is available at EcoGene: EG10303]. The FhuBCD ATP-dependent iron (III) hydroxamate transporter is a member of the ATP-Binding Cassette (ABC) Superfamily of transporters . [More information is available at EcoCyc: EG10303].
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    Genomic context

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    Sequence:
    NC_000913.3 (171462..173444)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene ferrichrome outer membrane transporter/phage receptor Neighboring gene iron(III) hydroxamate ABC transporter ATP binding subunit Neighboring gene iron(III) hydroxamate ABC transporter periplasmic binding protein Neighboring gene glutamate-1-semialdehyde 2,1-aminomutase Neighboring gene protein YadX

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Point mutations in two conserved glycine residues within the integral membrane protein FhuB affect iron(III) hydroxamate transport. Köster W, et al. Mol Gen Genet, 1992 Apr. PMID 1588908
    2. Genetic and biochemical characterization of the Escherichia coli K-12 fhuB mutation. Prody CA, et al. J Bacteriol, 1984 Mar. PMID 6321441, Free PMC Article
    3. Iron(III) hydroxamate transport of Escherichia coli: restoration of iron supply by coexpression of the N- and C-terminal halves of the cytoplasmic membrane protein FhuB cloned on separate plasmids. Köster W, et al. Mol Gen Genet, 1990 Sep. PMID 2270077
    4. Transmembrane topology of the two FhuB domains representing the hydrophobic components of bacterial ABC transporters involved in the uptake of siderophores, haem and vitamin B12. Groeger W, et al. Microbiology (Reading), 1998 Oct. PMID 9802017
    5. Genetic control of hydroxamate-mediated iron uptake in Escherichia coli. Kadner RJ, et al. J Bacteriol, 1980 Jul. PMID 6249788, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables siderophore uptake transmembrane transporter activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within ferric-hydroxamate import into cell EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in iron ion import across plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in iron ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in siderophore transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in siderophore-dependent iron import into cell IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of ATP-binding cassette (ABC) transporter complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    part_of ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    iron(III) hydroxamate ABC transporter membrane subunit
    NP_414695.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      171462..173444
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414695.1 iron(III) hydroxamate ABC transporter membrane subunit [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414695.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A377DYM9, A0A6M9WZA6
      Conserved Domains (1) summary
      PRK10577
      Location:1 → 660
      PRK10577; Fe(3+)-hydroxamate ABC transporter permease FhuB
    Nucleotide Protein
    Heading Accession and Version

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