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    pyrH UMP kinase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 944989, updated on 3-Dec-2024

    Summary

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    Official Symbol
    pyrH
    Official Full Name
    UMP kinase
    Primary source
    ECOCYC:EG11539
    Locus tag
    b0171
    See related
    ASAP:ABE-0000582
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0170; smbA; umk
    Summary
    Binds TrxA (Kumar, 2004). [More information is available at EcoGene: EG11539]. Expression of uridylate kinase is essential for growth of Escherichia coli . [More information is available at EcoCyc: EG11539].
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    Genomic context

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    Sequence:
    NC_000913.3 (191855..192580)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene 30S ribosomal subunit protein S2 Neighboring gene protein chain elongation factor EF-Ts Neighboring gene ribosome-recycling factor Neighboring gene 1-deoxy-D-xylulose 5-phosphate reductoisomerase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The site for the allosteric activator GTP of Escherichia coli UMP kinase. Marco-Marín C, et al. FEBS Lett, 2009 Jan 5. PMID 19071117
    2. Characterization of translucent segments observed in an smbA mutant of Escherichia coli. Yamanaka K, et al. FEMS Microbiol Lett, 1994 Feb 1. PMID 8132156
    3. A widely conserved developmental sensor in bacteria? Yorgey P, et al. Trends Genet, 1993 Nov. PMID 8310532
    4. Structural properties of UMP-kinase from Escherichia coli: modulation of protein solubility by pH and UTP. Serina L, et al. Biochemistry, 1996 Jun 4. PMID 8679525
    5. Mutational analysis of UMP kinase from Escherichia coli. Bucurenci N, et al. J Bacteriol, 1998 Feb. PMID 9457846, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on mature peptide
      Title: Escherichia coli UMP-kinase, a member of the aspartokinase family, is a hexamer regulated by guanine nucleotides and UTP.
    2. cross-talk mechanism between enzyme subunits involved in cooperative binding at the phosphate acceptor site and in allosteric regulation by GTP
      Title: Structure of Escherichia coli UMP kinase differs from that of other nucleoside monophosphate kinases and sheds new light on enzyme regulation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables UMP kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables UMP kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables UMP kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables UMP/dUMP kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 'de novo' CTP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in UDP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleoside monophosphate phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within pyrimidine nucleotide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in pyrimidine nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    UMP kinase
    NP_414713.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      191855..192580
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414713.1 UMP kinase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414713.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2X1NBT4
      Conserved Domains (1) summary
      cd04254
      Location:10 → 240
      AAK_UMPK-PyrH-Ec; UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and ...
    Nucleotide Protein
    Heading Accession and Version

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