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    nusB transcription antitermination protein NusB [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945054, updated on 3-Dec-2024

    Summary

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    Official Symbol
    nusB
    Official Full Name
    transcription antitermination protein NusB
    Primary source
    ECOCYC:EG10666
    Locus tag
    b0416
    See related
    ASAP:ABE-0001447
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0410; groNB; ssaD; ssyB
    Summary
    Transcription antitermination protein NusB is involved in antitermination in the transcription of a number of genes. [More information is available at EcoCyc: EG10666].
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    Genomic context

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    Sequence:
    NC_000913.3 (435137..435556)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene fused diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase Neighboring gene 6,7-dimethyl-8-ribityllumazine synthase Neighboring gene thiamine monophosphate kinase Neighboring gene phosphatidylglycerophosphatase A Neighboring gene 1-deoxyxylulose-5-phosphate synthase YajO

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cooperative effects of bacterial mutations affecting lambda N gene expression. I. Isolation and characterization of a nusB mutant. Friedman DI, et al. Virology, 1976 Aug. PMID 785802
    2. Involvement of the nusB gene products in transcription of Escherichia coli tryptophan operon in vitro. Kuroki K, et al. Mol Gen Genet, 1982. PMID 7045592
    3. ssaD1, a suppressor of secA51(Ts) that renders growth of Escherichia coli cold sensitive, is an early amber mutation in the transcription factor gene nusB. Rajapandi T, et al. J Bacteriol, 1994 Jul. PMID 8021230, Free PMC Article
    4. Molecular cloning and nucleotide sequencing of the nusB gene of E. coli. Ishii S, et al. Nucleic Acids Res, 1984 Jun 25. PMID 6330694, Free PMC Article
    5. Studies on the NusB protein of Escherichia coli--expression and determination of secondary-structure elements by multinuclear NMR spectroscopy. Berglechner F, et al. Eur J Biochem, 1997 Sep 1. PMID 9346286

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Conservation of putative NusB/E binding sites upstream of Nus factor genes suggests that Nus factor autoregulation occurs in many bacterial species.
      Title: Identification of regulatory targets for the bacterial Nus factor complex.
    2. Authors propose that another major role for the Nus-modified transcription complex in rrn operons is as an RNA chaperone insuring co-ordination of 16S rRNA folding and RNase III processing that results in production of proper 30S ribosome subunits.
      Title: Nus transcription elongation factors and RNase III modulate small ribosome subunit biogenesis in Escherichia coli.
    3. Strains carrying either a nusA mutation or a nusB mutation have defects in transcription of 23S rRNA.
      Title: Transcriptional polarity in rRNA operons of Escherichia coli nusA and nusB mutant strains.
    4. NusB and NusE (S10) proteins binding to boxA RNA nucleates the formation of the antitermination complex involved in controlling rRNA transcription in Escherichia coli
      Title: Assembly of an RNA-protein complex. Binding of NusB and NusE (S10) proteins to boxA RNA nucleates the formation of the antitermination complex involved in controlling rRNA transcription in Escherichia coli.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA-templated transcription termination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription elongation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription antitermination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transcription antitermination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transcription antitermination protein NusB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      435137..435556
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414950.1 transcription antitermination protein NusB [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414950.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A377B156
      Conserved Domains (1) summary
      PRK00202
      Location:11 → 139
      nusB; transcription antitermination factor NusB
    Nucleotide Protein
    Heading Accession and Version

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