purK 5-(carboxyamino)imidazole ribonucleotide synthase [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

Official Symbol: purK
Official Full Name: 5-(carboxyamino)imidazole ribonucleotide synthase
Primary source: ECOCYC:EG10796
Locus tag: b0522
See related: ASAP:ABE-0001794
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK0515; purE2
Summary: PurK was previously thought to be the ATPase subunit of phosphoribosylaminoimidazole carboxylase, with catalytic subunit PurE (Tiedeman, 1989). [More information is available at EcoGene: EG10796]. PurK and PurE were previously thought to be two subunits of AIR carboxylase , though more recent studies have shown the enzymes to be subunits of a distinct carboxylase and mutase, respectively . [More information is available at EcoCyc: EG10796].
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NC_000913.3 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Report is given of X-ray structures of N5-carboxyaminoimidazole ribonucleotide synthetase (CAIR) with either magnesium (Mg)ATP or MgADP/inorganic phosphorus (Pi) bound in the enzyme's active site cleft.
Title: Structural analysis of the active site geometry of N5-carboxyaminoimidazole ribonucleotide synthetase from Escherichia coli.
N-terminus verified by Edman degradation on complete protein
Title: Purification and characterization of the purE, purK, and purC gene products: identification of a previously unrecognized energy requirement in the purine biosynthetic pathway.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables 5-(carboxyamino)imidazole ribonucleotide synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables 5-(carboxyamino)imidazole ribonucleotide synthase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ligase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphoribosylaminoimidazole carboxylase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphoribosylaminoimidazole carboxylase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in 'de novo' IMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in purine nucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed

NP_415055.1

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The following sections contain reference sequences that belong to a specific genome build. Explain