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    ahpC alkyl hydroperoxide reductase, AhpC component [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945225, updated on 3-Dec-2024

    Summary

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    Official Symbol
    ahpC
    Official Full Name
    alkyl hydroperoxide reductase, AhpC component
    Primary source
    ECOCYC:EG11384
    Locus tag
    b0605
    See related
    ASAP:ABE-0002090
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0599; ssi8; tpx
    Summary
    AhpCF protects aerobic, phosphate-starved cells from oxidative damage. [More information is available at EcoGene: EG11384]. The AhpC component carries out the actual reduction of the hydroperoxide substrate. [More information is available at EcoCyc: EG11384].
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    Genomic context

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    Sequence:
    NC_000913.3 (638945..639508)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative LysR family DNA-binding transcriptional regulator YbdO Neighboring gene protein sulfenic acid reductase and chaperone DsbG Neighboring gene alkyl hydroperoxide reductase, AhpF component Neighboring gene universal stress protein G

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Key roles of the Escherichia coli AhpC C-terminus in assembly and catalysis of alkylhydroperoxide reductase, an enzyme essential for the alleviation of oxidative stress. Dip PV, et al. Biochim Biophys Acta, 2014 Dec. PMID 25193562
    2. AhpC is required for optimal production of enterobactin by Escherichia coli. Ma L, et al. J Bacteriol, 2012 Dec. PMID 23042987, Free PMC Article
    3. Structure, mechanism and ensemble formation of the alkylhydroperoxide reductase subunits AhpC and AhpF from Escherichia coli. Dip PV, et al. Acta Crystallogr D Biol Crystallogr, 2014 Nov. PMID 25372677
    4. Bacterial defenses against oxidants: mechanistic features of cysteine-based peroxidases and their flavoprotein reductases. Poole LB. Arch Biochem Biophys, 2005 Jan 1. PMID 15581580
    5. AhpF can be dissected into two functional units: tandem repeats of two thioredoxin-like folds in the N-terminus mediate electron transfer from the thioredoxin reductase-like C-terminus to AhpC. Poole LB, et al. Biochemistry, 2000 Jun 6. PMID 10828978

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. a concerted movement involving the NTD, C-terminal NADH, and FAD domains, and the flexible linker between them in AhpF is essential for optimal intra-domain cross-talk and for efficient electron transfer to the redox partner AhpC required for peroxidation
      Title: Essential role of the flexible linker on the conformational equilibrium of bacterial peroxiredoxin reductase for effective regeneration of peroxiredoxin.
    2. Data show that the very C-terminus of the oxidized alkyl hydroperoxide reductase C22 subunit AhpC is oriented away from the dimer interface and away from the catalytic redox-center.
      Title: Key roles of the Escherichia coli AhpC C-terminus in assembly and catalysis of alkylhydroperoxide reductase, an enzyme essential for the alleviation of oxidative stress.
    3. AhpC is required for optimal production of enterobactin; data suggested that AhpC affected the activity of EntC or the availability of the chorismate substrate
      Title: AhpC is required for optimal production of enterobactin by Escherichia coli.
    4. N-terminus verified by Edman degradation on mature peptide
      Title: Indole-inducible proteins in bacteria suggest membrane and oxidant toxicity.
    5. Hpx- (katG katE ahpCF) mutants of Escherichia coli have DNA damage from submicromolar intracellular hydrogen peroxide
      Title: Substantial DNA damage from submicromolar intracellular hydrogen peroxide detected in Hpx- mutants of Escherichia coli.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables NADH-dependent peroxiredoxin activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydroperoxide reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables oxidoreductase activity, acting on peroxide as acceptor IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables peroxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peroxidase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables peroxiredoxin activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables thioredoxin peroxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell redox homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cellular response to sulfate starvation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in hydrogen peroxide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in hydrogen peroxide catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to alkyl hydroperoxide IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to hydroperoxide IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to oxidative stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to oxidative stress NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in siderophore biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of alkyl hydroperoxide reductase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of alkyl hydroperoxide reductase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane HDA PubMed 

    General protein information

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    Preferred Names
    alkyl hydroperoxide reductase, AhpC component
    NP_415138.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      638945..639508
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415138.1 alkyl hydroperoxide reductase, AhpC component [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415138.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5B9AKJ5
      Conserved Domains (1) summary
      PRK10382
      Location:1 → 187
      PRK10382; alkyl hydroperoxide reductase subunit C; Provisional
    Nucleotide Protein
    Heading Accession and Version

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