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    cydC glutathione/L-cysteine ABC exporter subunit CydC [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945504, updated on 3-Dec-2024

    Summary

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    Official Symbol
    cydC
    Official Full Name
    glutathione/L-cysteine ABC exporter subunit CydC
    Primary source
    ECOCYC:EG10012
    Locus tag
    b0886
    See related
    ASAP:ABE-0003012
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0877; mdrA; mdrH; surB; ycaB
    Summary
    The cydDC operon encodes two ATP-binding cassette (ABC) transporter proteins that are most closely similar to ABC transporters involved in export . [More information is available at EcoCyc: EG10012].
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    Genomic context

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    Sequence:
    NC_000913.3 (927474..929195, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene translation initiation factor IF-1 Neighboring gene leucyl/phenylalanyl-tRNA--protein transferase Neighboring gene glutathione/L-cysteine ABC exporter subunit CydD Neighboring gene thioredoxin reductase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The stationary-phase-exit defect of cydC (surB) mutants is due to the lack of a functional terminal cytochrome oxidase. Siegele DA, et al. J Bacteriol, 1996 Nov. PMID 8892804, Free PMC Article
    2. Escherichia coli K-12 on the internet. Rudd KE. Trends Genet, 1996 Apr. PMID 8901421
    3. CydDC-mediated reductant export in Escherichia coli controls the transcriptional wiring of energy metabolism and combats nitrosative stress. Holyoake LV, et al. Biochem J, 2016 Mar 15. PMID 26699904, Free PMC Article
    4. The CydDC ABC transporter of Escherichia coli: new roles for a reductant efflux pump. Shepherd M. Biochem Soc Trans, 2015 Oct. PMID 26517902
    5. The CydDC Family of Transporters and Their Roles in Oxidase Assembly and Homeostasis. Holyoake LV, et al. Adv Microb Physiol, 2015. PMID 26210105

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ABC-type heme transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in amino acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell redox homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell redox homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell redox homeostasis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in cysteine export across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cysteine export across plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cysteine export across plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in cytochrome biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glutathione transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glutathione transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glutathione transmembrane transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in heme transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of ATP-binding cassette (ABC) transporter complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of ATP-binding cassette (ABC) transporter complex, integrated substrate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glutathione/L-cysteine ABC exporter subunit CydC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      927474..929195 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415406.1 glutathione/L-cysteine ABC exporter subunit CydC [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415406.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6M9WS44
      Conserved Domains (1) summary
      PRK11160
      Location:1 → 573
      PRK11160; cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed
    Nucleotide Protein
    Heading Accession and Version

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