lrp DNA-binding transcriptional dual regulator Lrp [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

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Official Symbol: lrp
Official Full Name: DNA-binding transcriptional dual regulator Lrp
Primary source: ECOCYC:EG10547
Locus tag: b0889
See related: ASAP:ABE-0003023
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: alsB; ECK0880; ihb; livR; lrs; lss; lstR; mbf; oppI; rblA
Summary: Feast/famine regulatory protein. [More information is available at EcoGene: EG10547]. The Lrp protein belongs to the AsnC family. [More information is available at EcoCyc: EG10547].
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Genomic context

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Sequence:: NC_000913.3 (932595..933089)

NC_000913.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The overall regulatory behavior of Lrp, which as the authors now show extends to 38% of Escherichia coli genes directly or indirectly under at least one condition, thus arises from the interaction between changes in Lrp binding specificity and cooperative action with other regulators.
Title: Escherichia coli Lrp Regulates One-Third of the Genome via Direct, Cooperative, and Indirect Routes.
the gene expression of the alaE is regulated by Lrp in response to intracellular levels of l-alanine, which eventually leads to intracellular homeostasis of l-alanine concentrations
Title: Expression of the alaE gene is positively regulated by the global regulator Lrp in response to intracellular accumulation of l-alanine in Escherichia coli.
These results suggest that the preferential OFF state observed in CS31A cells is mainly due to the weak interaction of the leucine-responsive regulatory protein with the clp distal region and that the PapI homolog favors the OFF phase.
Title: Leucine-responsive regulatory protein Lrp and PapI homologues influence phase variation of CS31A fimbriae.
MicF activates genes in the Lrp regulon by repressing Lrp, and causes impaired growth in minimal medium.
Title: A mixed double negative feedback loop between the sRNA MicF and the global regulator Lrp.
we identified two nucleotides (T490, G508) surrounding the Lrp binding site 1 that are critical to maintaining a high OFF to ON switch rate during F1651 phase variation, as well as switching Pap fimbriae towards the OFF state.
Title: Lrp-DNA complex stability determines the level of ON cells in type P fimbriae phase variation.
The N-terminal tail plays a significant role in modulating Lrp function in DNA recognition.
Title: Recognition of DNA by the helix-turn-helix global regulatory protein Lrp is modulated by the amino terminus.
These results indicate that ArgP is a major regulator of lysP expression but that Lrp modulates lysP transcription under lysine-limiting conditions.
Title: Identification of ArgP and Lrp as transcriptional regulators of lysP, the gene encoding the specific lysine permease of Escherichia coli.
Binding of the IHF protein to a site immediately adjacent to fimS is required for phase-on orientational bias; in the absence of LRP and IHF binding, fimS adopts the off orientation and the H-NS protein is required to maintain this orientational bias.
Title: DNA relaxation-dependent phase biasing of the fim genetic switch in Escherichia coli depends on the interplay of H-NS, IHF and LRP.
Activation by Lrp interferes with the previously demonstrated activation of the argO promoter by ArgP.
Title: Competitive activation of the Escherichia coli argO gene coding for an arginine exporter by the transcriptional regulators Lrp and ArgP.
the regulatory motifs for different amino acid fall into the traditional classification of amino acid families, thus elucidating the structure and physiological functions of the Lrp-regulon
Title: Genome-scale reconstruction of the Lrp regulatory network in Escherichia coli.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by EcoCyc

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription activator activity	IPI Inferred from Physical Interaction more info	PubMed
enables DNA-binding transcription repressor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription repressor activity	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables transcription cis-regulatory region binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables transcription cis-regulatory region binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in alanine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of DNA-templated transcription	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to L-leucine	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to L-leucine	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
part_of protein-DNA complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of protein-DNA complex	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: DNA-binding transcriptional dual regulator Lrp

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_000913.3 Reference assembly

Range

932595..933089

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NP_415409.1 DNA-binding transcriptional dual regulator Lrp [Escherichia coli str. K-12 substr. MG1655]

See identical proteins and their annotated locations for NP_415409.1

Status: PROVISIONAL

UniProtKB/TrEMBL

Q14F19

Conserved Domains (1) summary

PRK11169
Location:1 → 164

PRK11169; leucine-responsive transcriptional regulator Lrp