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    cbpM chaperone modulator CbpM [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945597, updated on 17-Dec-2024

    Summary

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    Official Symbol
    cbpM
    Official Full Name
    chaperone modulator CbpM
    Primary source
    ECOCYC:EG12194
    Locus tag
    b0999
    See related
    ASAP:ABE-0003377
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0990; yccD
    Summary
    Purified CbpM protein specifically inhibits both the DNA binding and co-chaperone activity of CbpA . [More information is available at EcoCyc: EG12194].
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    Genomic context

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    Sequence:
    NC_000913.3 (1062550..1062855, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene cytochrome c menaquinol dehydrogenase TorC Neighboring gene trimethylamine N-oxide reductase 1 Neighboring gene trimethylamine-N-oxide reductase-specific chaperone Neighboring gene curved DNA-binding protein Neighboring gene uncharacterized protein YccE

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A conserved acidic amino acid mediates the interaction between modulators and co-chaperones in enterobacteria. Chintakayala K, et al. J Mol Biol, 2011 Aug 12. PMID 21683710
    2. Complex regulation of the DnaJ homolog CbpA by the global regulators sigmaS and Lrp, by the specific inhibitor CbpM, and by the proteolytic degradation of CbpM. Chenoweth MR, et al. J Bacteriol, 2008 Aug. PMID 18502857, Free PMC Article
    3. Functional analysis of CbpA, a DnaJ homolog and nucleoid-associated DNA-binding protein. Bird JG, et al. J Biol Chem, 2006 Nov 10. PMID 16973605
    4. An analogue of the DnaJ molecular chaperone whose expression is controlled by sigma s during the stationary phase and phosphate starvation in Escherichia coli. Yamashino T, et al. Mol Microbiol, 1994 Aug. PMID 7997164
    5. An analogue of the DnaJ molecular chaperone in Escherichia coli. Ueguchi C, et al. Proc Natl Acad Sci U S A, 1994 Feb 1. PMID 8302830, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The activity of CbpA is regulated by the "modulator" protein CbpM.
      Title: A conserved acidic amino acid mediates the interaction between modulators and co-chaperones in enterobacteria.
    2. When not bound to CbpA, CbpM was unstable and was degraded by the Lon and ClpAP proteases.
      Title: Complex regulation of the DnaJ homolog CbpA by the global regulators sigmaS and Lrp, by the specific inhibitor CbpM, and by the proteolytic degradation of CbpM.
    3. We discovered that CbpM specifically inhibits the in vivo activity of CbpA, preventing it from functioning in cell growth and division.
      Title: In vivo modulation of a DnaJ homolog, CbpA, by CbpM.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables enzyme inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    chaperone modulator CbpM

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1062550..1062855 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415519.1 chaperone modulator CbpM [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415519.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A829L0K3, A0AAN3UZ95
      Conserved Domains (1) summary
      PRK10265
      Location:1 → 101
      PRK10265; chaperone modulator CbpM
    Nucleotide Protein
    Heading Accession and Version

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