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    clsA cardiolipin synthase A [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945821, updated on 3-Dec-2024

    Summary

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    Official Symbol
    clsA
    Official Full Name
    cardiolipin synthase A
    Primary source
    ECOCYC:EG11608
    Locus tag
    b1249
    See related
    ASAP:ABE-0004186
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    cls; ECK1243; nov; yciJ
    Summary
    Overexpression causes filamentous biofilm formation. [More information is available at EcoGene: EG11608].
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    Genomic context

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    Sequence:
    NC_000913.3 (1307185..1308645, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene murein tripeptide ABC transporter/oligopeptide ABC transporter ATP binding subunit OppD Neighboring gene murein tripeptide ABC transporter/oligopeptide ABC transporter ATP binding subunit OppF Neighboring gene DUF440 domain-containing protein YciU Neighboring gene uncharacterized protein YciY Neighboring gene K(+) channel Kch

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Active increase in cardiolipin synthesis in the stationary growth phase and its physiological significance in Escherichia coli. Hiraoka S, et al. FEBS Lett, 1993 Dec 27. PMID 8262233
    2. The effects of phosphoglycerides on Escherichia coli cardiolipin synthase. Ragolia L, et al. Biochim Biophys Acta, 1994 Oct 6. PMID 7918616
    3. nov: a new genetic locus that affects the response of Escherichia coli K-12 to novobiocin. Rakonjac J, et al. Mol Microbiol, 1992 Jun. PMID 1625583
    4. Genetic regulation of cardiolipin synthase in Escherichia coli. Heber S, et al. Biochim Biophys Acta, 1991 Dec 2. PMID 1661609
    5. E. coli cardiolipin synthase: function of N-terminal conserved residues. Quigley BR, et al. Biochim Biophys Acta, 2009 Oct. PMID 19341704

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results have demonstrated that ClsA is able to produce phosphatidylalcohols in the presence of a foreign lipid class, but not when only endogenous phospholipids are present.
      Title: Cardiolipin synthases of Escherichia coli have phospholipid class specific phospholipase D activity dependent on endogenous and foreign phospholipids.
    2. this study provides new information regarding the structure, membrane topology and subcellular localization of ClsA, revealing that targeted cardiolilin (CL) synthesis may contribute to the polar localization of CL, ClsA and ProP.
      Title: Cardiolipin synthase A colocalizes with cardiolipin and osmosensing transporter ProP at the poles of Escherichia coli cells.
    3. Data indicate that the cardiolipin synthase DeltaclsABC mutant (clsA, clsB(ybhO) and clsC (ymdC))nlacks detectible cardiolipin (CL) regardless of growth phase or growth conditions.
      Title: Discovery of a cardiolipin synthase utilizing phosphatidylethanolamine and phosphatidylglycerol as substrates.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables cardiolipin synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cardiolipin synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cardiolipin synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphotransferase activity, for other substituted phosphate groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cardiolipin biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cardiolipin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cardiolipin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell pole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cardiolipin synthase A
    NP_415765.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1307185..1308645 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415765.1 cardiolipin synthase A [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415765.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5B9AN58, A0A8T5ZB79
      Conserved Domains (1) summary
      PRK01642
      Location:5 → 486
      cls; cardiolipin synthetase; Reviewed
    Nucleotide Protein
    Heading Accession and Version

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