U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    lsrG (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946073, updated on 3-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    lsrG
    Official Full Name
    (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase
    Primary source
    ECOCYC:G6805
    Locus tag
    b1518
    See related
    ASAP:ABE-0005067
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1511; yneC
    Summary
    LsrG is part of an operon for autoinducer-2 (AI-2) uptake regulated by LsrR and LuxS, through AI-2. [More information is available at EcoGene: EG13811]. LsrG is an enzyme involved in the degradation of the quorum-sensing regulator Autoinducer 2 (AI-2). [More information is available at EcoCyc: G6805].
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_000913.3 (1606999..1607289)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene Autoinducer-2 ABC transporter periplasmic binding protein Neighboring gene 3-hydroxy-2,4-pentadione 5-phosphate thiolase Neighboring gene trans-aconitate 2-methyltransferase Neighboring gene PF01062 family inner membrane protein YneE

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Processing the interspecies quorum-sensing signal autoinducer-2 (AI-2): characterization of phospho-(S)-4,5-dihydroxy-2,3-pentanedione isomerization by LsrG protein. Marques JC, et al. J Biol Chem, 2011 May 20. PMID 21454635, Free PMC Article
    2. Phosphorylation and processing of the quorum-sensing molecule autoinducer-2 in enteric bacteria. Xavier KB, et al. ACS Chem Biol, 2007 Feb 20. PMID 17274596
    3. Lsr-mediated transport and processing of AI-2 in Salmonella typhimurium. Taga ME, et al. Mol Microbiol, 2003 Nov. PMID 14622426
    4. The LuxS-dependent autoinducer AI-2 controls the expression of an ABC transporter that functions in AI-2 uptake in Salmonella typhimurium. Taga ME, et al. Mol Microbiol, 2001 Nov. PMID 11722742
    5. Regulation of uptake and processing of the quorum-sensing autoinducer AI-2 in Escherichia coli. Xavier KB, et al. J Bacteriol, 2005 Jan. PMID 15601708, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables intramolecular oxidoreductase activity, interconverting aldoses and ketoses IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables isomerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in quorum sensing IC
    Inferred by Curator
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase
    NP_416035.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1606999..1607289
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416035.1 (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416035.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376S8V7, W1F1C6
      Conserved Domains (1) summary
      PRK10486
      Location:1 → 96
      PRK10486; (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.