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    mepM peptidoglycan endopeptidase MepM [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946376, updated on 3-Dec-2024

    Summary

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    Official Symbol
    mepM
    Official Full Name
    peptidoglycan endopeptidase MepM
    Primary source
    ECOCYC:EG10013
    Locus tag
    b1856
    See related
    ASAP:ABE-0006189
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1857; yebA
    Summary
    NlpD, YgeR, YebA and EnvC are paralogs. [More information is available at EcoGene: EG10013].
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    Genomic context

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    Sequence:
    NC_000913.3 (1940313..1941635, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene pyruvate kinase 2 Neighboring gene Lipid A biosynthesis myristoyltransferase Neighboring gene Zn(2(+)) ABC transporter periplasmic binding protein Neighboring gene Zn(2(+)) ABC transporter ATP binding subunit Neighboring gene Zn(2(+)) ABC transporter membrane subunit

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Peptidoglycan endopeptidase MepM of uropathogenic Escherichia coli contributes to competitive fitness during urinary tract infections. Huang WC, et al. BMC Microbiol, 2024 May 30. PMID 38816687, Free PMC Article
    2. Isolation and characterization of the Escherichia coli msbB gene, a multicopy suppressor of null mutations in the high-temperature requirement gene htrB. Karow M, et al. J Bacteriol, 1992 Feb. PMID 1732206, Free PMC Article
    3. Outer membrane lipoprotein NlpI scaffolds peptidoglycan hydrolases within multi-enzyme complexes in Escherichia coli. Banzhaf M, et al. EMBO J, 2020 Mar 2. PMID 32009249, Free PMC Article
    4. LytM-domain factors are required for daughter cell separation and rapid ampicillin-induced lysis in Escherichia coli. Uehara T, et al. J Bacteriol, 2009 Aug. PMID 19525345, Free PMC Article
    5. Three redundant murein endopeptidases catalyse an essential cleavage step in peptidoglycan synthesis of Escherichia coli K12. Singh SK, et al. Mol Microbiol, 2012 Dec. PMID 23062283

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Peptidoglycan endopeptidase MepM of uropathogenic Escherichia coli contributes to competitive fitness during urinary tract infections.
      Title: Peptidoglycan endopeptidase MepM of uropathogenic Escherichia coli contributes to competitive fitness during urinary tract infections.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in capsule polysaccharide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell wall organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within peptidoglycan metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in peptidoglycan turnover IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    peptidoglycan endopeptidase MepM

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1940313..1941635 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416370.2 peptidoglycan endopeptidase MepM [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416370.2

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376KUB4, A0A8H9SED5, A0AAN4IYU3
      Conserved Domains (1) summary
      PRK11649
      Location:1 → 440
      PRK11649; putative peptidase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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