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    fliG flagellar motor switch protein FliG [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946451, updated on 3-Dec-2024

    Summary

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    Official Symbol
    fliG
    Official Full Name
    flagellar motor switch protein FliG
    Primary source
    ECOCYC:EG11654
    Locus tag
    b1939
    See related
    ASAP:ABE-0006456
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1937; flaAII.2; flaBII
    Summary
    FliGMN switch complex on the rotor of the bacterial flagellum. [More information is available at EcoGene: EG11654]. FliG is one of three components of the flagellar motor's "switch complex. [More information is available at EcoCyc: EG11654].
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    Genomic context

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    Sequence:
    NC_000913.3 (2014880..2015875)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene pseudo Neighboring gene flagellar protein FliE Neighboring gene flagellar basal-body MS-ring and collar protein Neighboring gene flagellar biosynthesis protein FliH Neighboring gene flagellar export ATPase FliI Neighboring gene flagellar biosynthesis protein FliJ Neighboring gene flagellar hook-length control protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rusty, jammed, and well-oiled hinges: Mutations affecting the interdomain region of FliG, a rotor element of the Escherichia coli flagellar motor. Van Way SM, et al. J Bacteriol, 2004 May. PMID 15126479, Free PMC Article
    2. Architecture of the Flagellar Switch Complex of Escherichia coli: Conformational Plasticity of FliG and Implications for Adaptive Remodeling. Kim EA, et al. J Mol Biol, 2017 May 5. PMID 28259628, Free PMC Article
    3. Domain-swap polymerization drives the self-assembly of the bacterial flagellar motor. Baker MA, et al. Nat Struct Mol Biol, 2016 Mar. PMID 26854663
    4. A Mechanism of Modulating the Direction of Flagellar Rotation in Bacteria by Fumarate and Fumarate Reductase. Koganitsky A, et al. J Mol Biol, 2019 Sep 6. PMID 31412261, Free PMC Article
    5. The conserved charged residues of the C-terminal region of FliG, a rotor component of the Na+-driven flagellar motor. Yorimitsu T, et al. J Mol Biol, 2003 Nov 28. PMID 14623195

    See all (76) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The results indicate that FliG has a significant tendency to form multimers independently of other flagellar components. The multimerization of FliG is promoted by FliF and also by FliM.
      Title: Biogenesis of the Flagellar Switch Complex in Escherichia coli: Formation of Sub-Complexes Independently of the Basal-Body MS-Ring.
    2. The results indicate a copy number of ~25 for FliG in the complex that regulates the direction of flagellar rotation.
      Title: Architecture of the Flagellar Switch Complex of Escherichia coli: Conformational Plasticity of FliG and Implications for Adaptive Remodeling.
    3. FliG exists predominantly as a monomer in solution but only as domain-swapped polymers in assembled flagellar motors.
      Title: Domain-swap polymerization drives the self-assembly of the bacterial flagellar motor.
    4. The biophysical characterization of this protein is determined.
      Title: Biophysical characterization of the C-terminal region of FliG, an essential rotor component of the Na+-driven flagellar motor.
    5. FliG molecules with pairs of Cys residues in the middle domain formed disulfide-linked dimers and larger multimers, so the middle domains of adjacent subunits are in fairly close proximity and putting constraints on the relative orientation of the domains
      Title: FliG subunit arrangement in the flagellar rotor probed by targeted cross-linking.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables cytoskeletal motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in archaeal or bacterial-type flagellum-dependent cell motility IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within bacterial-type flagellum assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in bacterial-type flagellum-dependent cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in bacterial-type flagellum-dependent cell motility IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within bacterial-type flagellum-dependent cell motility IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in bacterial-type flagellum-dependent swimming motility NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chemotaxis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in bacterial-type flagellum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in bacterial-type flagellum NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in bacterial-type flagellum basal body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in bacterial-type flagellum basal body, C ring NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in bacterial-type flagellum rotor complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    flagellar motor switch protein FliG

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2014880..2015875
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416449.1 flagellar motor switch protein FliG [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416449.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A779UC74, A0A8S7ENK9
      Conserved Domains (1) summary
      TIGR00207
      Location:1 → 331
      fliG; flagellar motor switch protein FliG
    Nucleotide Protein
    Heading Accession and Version

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