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    hiuH hydroxyisourate hydrolase/transthyretin-related protein [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946485, updated on 17-Dec-2024

    Summary

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    Official Symbol
    hiuH
    Official Full Name
    hydroxyisourate hydrolase/transthyretin-related protein
    Primary source
    ECOCYC:G7058
    Locus tag
    b1970
    See related
    ASAP:ABE-0006537
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1966; yedX
    Summary
    Purified Escherichia coli HiuH(YedX) hydrolyzes 5-hydroxyisourate producing both allantoin and the intermediate 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) which will spontaneously decay into a racemic mixture of R- and S-allantoin but AllB allantoinase metabolizes S-allantoin only, so HiuH may also have OHCU decarboxylase activity (Lee, 2005; Hennebry, 2006). [More information is available at EcoGene: EG14046]. YedX belongs to the family of transthyretin-related proteins (TRP). [More information is available at EcoCyc: G7058].
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    Genomic context

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    Sequence:
    NC_000913.3 (2038956..2039369)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene protein/nucleic acid deglycase 1 Neighboring gene sensor histidine kinase HprS Neighboring gene DNA-binding transcriptional dual regulator HprR Neighboring gene protein-L-methionine sulfoxide reductase catalytic subunit MsrP Neighboring gene membrane-bound flavocytochrome MsrQ

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural and functional evolution of transthyretin and transthyretin-like proteins. Hennebry SC, et al. Proteins, 2006 Sep 1. PMID 16783790
    2. The evolution of transthyretin synthesis in vertebrate liver, in primitive eukaryotes and in bacteria. Richardson SJ. Clin Chem Lab Med, 2002 Dec. PMID 12553419
    3. Evolution of the thyroid hormone distributor protein transthyretin in microbes, C. elegans, and vertebrates. Richardson SJ, et al. Ann N Y Acad Sci, 2005 Apr. PMID 15891085
    4. The transthyretin-related protein family. Eneqvist T, et al. Eur J Biochem, 2003 Feb. PMID 12542701
    5. The transthyretin-related protein: structural investigation of a novel protein family. Lundberg E, et al. J Struct Biol, 2006 Sep. PMID 16723258

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydroxyisourate hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydroxyisourate hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein homotetramerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in purine nucleobase metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in purine nucleobase metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in periplasmic space IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    hydroxyisourate hydrolase/transthyretin-related protein
    NP_416479.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2038956..2039369
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416479.1 hydroxyisourate hydrolase/transthyretin-related protein [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416479.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A7D7P8Y0
      Conserved Domains (1) summary
      PRK15036
      Location:1 → 137
      PRK15036; hydroxyisourate hydrolase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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