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    dusC tRNA-dihydrouridine(16) synthase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945458, updated on 17-Dec-2024

    Summary

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    Official Symbol
    dusC
    Official Full Name
    tRNA-dihydrouridine(16) synthase
    Primary source
    ECOCYC:EG12022
    Locus tag
    b2140
    See related
    ASAP:ABE-0007074
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2133; yohI
    Summary
    DusB and DusC together account for about half of the 5,6-dihydrouridine modification observed in wild-type cellular tRNA, and DusA accounts for the other half . [More information is available at EcoCyc: EG12022].
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    Genomic context

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    Sequence:
    NC_000913.3 (2229438..2230385, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene putative membrane protein YohP Neighboring gene putative 3-hydroxypropanoate export protein YohJ Neighboring gene putative 3-hydroxypropanoate export protein YohK Neighboring gene cytidine/deoxycytidine deaminase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Major reorientation of tRNA substrates defines specificity of dihydrouridine synthases. Byrne RT, et al. Proc Natl Acad Sci U S A, 2015 May 12. PMID 25902496, Free PMC Article
    2. Identification of the tRNA-dihydrouridine synthase family. Bishop AC, et al. J Biol Chem, 2002 Jul 12. PMID 11983710
    3. Comparative genomics and evolution of proteins involved in RNA metabolism. Anantharaman V, et al. Nucleic Acids Res, 2002 Apr 1. PMID 11917006, Free PMC Article
    4. Large-scale identification of protein-protein interaction of Escherichia coli K-12. Arifuzzaman M, et al. Genome Res, 2006 May. PMID 16606699, Free PMC Article
    5. Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Hayashi K, et al. Mol Syst Biol, 2006. PMID 16738553, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables FMN binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables FMN binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA dihydrouridine synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables tRNA dihydrouridine synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA dihydrouridine synthase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables tRNA-dihydrouridine16 synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in gene expression IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA dihydrouridine synthesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tRNA dihydrouridine synthesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tRNA-dihydrouridine(16) synthase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2229438..2230385 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416645.1 tRNA-dihydrouridine(16) synthase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416645.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5B9AL14, A0A7A6N818
      Conserved Domains (1) summary
      PRK10550
      Location:1 → 312
      PRK10550; tRNA dihydrouridine(16) synthase DusC
    Nucleotide Protein
    Heading Accession and Version

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