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    fruA fructose-specific PTS multiphosphoryl transfer protein FruA [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946672, updated on 17-Dec-2024

    Summary

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    Official Symbol
    fruA
    Official Full Name
    fructose-specific PTS multiphosphoryl transfer protein FruA
    Primary source
    ECOCYC:EG10336
    Locus tag
    b2167
    See related
    ASAP:ABE-0007172
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2160; ptsF
    Summary
    C-terminal domain, last 200 residues, is member of LysE superfamily. [More information is available at EcoGene: EG10336]. This subunit contains PTS Enzyme IIB', IIB and IIC domains. [More information is available at EcoCyc: EG10336].
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    Genomic context

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    Sequence:
    NC_000913.3 (2259719..2261410, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative pseudouridine transporter Neighboring gene pseudouridine-5'-phosphate glycosidase Neighboring gene putative pseudouridine kinase Neighboring gene 1-phosphofructokinase Neighboring gene fructose-specific PTS multiphosphoryl transfer protein FruB

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A preliminary X-ray study of a refolded PTS EIIBfruc protein from Escherichia coli. Shin DH. Protein Pept Lett, 2008. PMID 18680461
    2. [Analysis of mutations affecting the expression of catabolite-sensitive operons in Escherichia coli K12 mutants defective in the HPr-component of the carbohydrate transport system]. Erlagaeva RS, et al. Mol Gen Mikrobiol Virusol, 1987 Feb. PMID 3553910
    3. [Determination of the direction of transcription of Escherichia coli K-12 structural genes of the fructose regulon in vivo]. Dobrynina OIu, et al. Genetika, 1995 Feb. PMID 7721070
    4. Physiological consequences of the complete loss of phosphoryl-transfer proteins HPr and FPr of the phosphoenolpyruvate:sugar phosphotransferase system and analysis of fructose (fru) operon expression in Salmonella typhimurium. Feldheim DA, et al. J Bacteriol, 1990 Sep. PMID 2203752, Free PMC Article
    5. The PEP: fructose phosphotransferase system in Salmonella typhimurium: FPr combines enzyme IIIFru and pseudo-HPr activities. Geerse RH, et al. Mol Gen Genet, 1989 Apr. PMID 2546043

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The synchrotron data were collected to 2.6 A from the crystal of a selenomethionine substitute PTS EIIB(fruc) protein.
      Title: A preliminary X-ray study of a refolded PTS EIIBfruc protein from Escherichia coli.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables carbohydrate:proton symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein-phosphocysteine-sugar phosphotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within fructose import across plasma membrane EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in fructose import across plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phosphoenolpyruvate-dependent sugar phosphotransferase system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphoenolpyruvate-dependent sugar phosphotransferase system IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phosphoenolpyruvate-dependent sugar phosphotransferase system IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phosphoenolpyruvate-dependent sugar phosphotransferase system IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphoenolpyruvate-dependent sugar phosphotransferase system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    part_of transmembrane transporter complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    fructose-specific PTS multiphosphoryl transfer protein FruA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2259719..2261410 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416672.1 fructose-specific PTS multiphosphoryl transfer protein FruA [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416672.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A1V2GKJ1
      Conserved Domains (1) summary
      PRK10712
      Location:1 → 563
      PRK10712; PTS system fructose-specific transporter subunits IIBC; Provisional
    Nucleotide Protein
    Heading Accession and Version

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